Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis are generally
thought to have high mortality rates. However, many cases can be treated with the right …

Background Rifampicin (RIF) plays a pivotal role in the treatment of tuberculosis due to its
bactericidal effects. Because the action of RIF is on rpoB gene encoding RNA polymerase β …

Mycobacterium tuberculosis remains one of the most significant causes of death from an
infectious agent. The rapid diagnosis of tuberculosis and detection of rifampin (RIF) …

The MTBDR plus line probe assay (LPA) and Xpert MTB/RIF have been endorsed by the
World Health Organization for the rapid diagnosis of drug-resistant tuberculosis. However …

Background Mycobacterium tuberculosis is a leading cause of death worldwide. In multi-
drug resistant tuberculosis (MDR-TB) infectiousness is frequently prolonged, jeopardizing …

Tuberculosis chemotherapy is dependent on the use of the antibiotic pyrazinamide, which is
being threatened by emerging drug resistance. Resistance is mediated through mutations in …

Bacterial persisters are a subpopulation of cells that can tolerate lethal concentrations of
antibiotics. However, the possibility of the emergence of genetically resistant mutants from …

The enormous genetic flexibility of bacteria jeopardizes the usefulness of currently available
antibiotics, and requires new approaches to antibiotic discovery and development …

Nine structural genes (furA, katG, inhA, kasA, Rv0340, iniB, iniA, iniC, and efpA) and two
regulatory regions (the oxyR-ahpC intergenic region and the promoter of mabA-inhA) in 87 …

Mycobacteria are a group of acid-fast, aerobic, slow-growing organisms whose genus
includes more than 90 different species. The causative agents of tuberculosis (TB), which is …