Influenza viruses replicate within the nucleus of the host cell. This uncommon RNA virus trait
provides influenza with the advantage of access to the nuclear machinery during replication …

The genomes of influenza viruses consist of multiple segments of single-stranded negative-
sense RNA. Each of these segments is bound by the heterotrimeric viral RNA-dependent …

Influenza A viral ribonucleoprotein (vRNP) complexes comprise the eight genomic negative-
sense RNAs, each of which is bound to multiple copies of the vRNP and a trimeric viral …

Influenza virus contains a single-stranded negative-sense RNA genome. Replication of the
genome is carried out by the viral RNA-dependent RNA polymerase in the context of the …

Influenza virus polymerase uses a capped primer, derived by 'cap-snatching'from host pre-
messenger RNA, to transcribe its RNA genome into mRNA and a stuttering mechanism to …

Viruses use virions to spread between hosts, and virion composition is therefore the primary
determinant of viral transmissibility and immunogenicity. However, the virions of many …

Influenza A viruses are responsible for seasonal epidemics, and pandemics can arise from
the transmission of novel zoonotic influenza A viruses to humans,. Influenza A viruses …

The host interferon (IFN) response represents one of the first barriers that influenza viruses
must surmount in order to establish an infection. Many advances have been made in recent …

Eukaryotes and bacteria can be infected with a wide variety of RNA viruses. On average,
these pathogens share little sequence similarity and use different replication and …

Influenza virus is a segmented, negative strand RNA virus with each genome segment being
packaged in a distinct ribonucleoprotein particle (RNP). The RNP consists of the …