Intracellular microbial rhodopsin-based optogenetics to control metabolism and cell signaling

AD Vlasova, SM Bukhalovich, DF Bagaeva… - Chemical Society …, 2024 - pubs.rsc.org
Microbial rhodopsin (MRs) ion channels and pumps have become invaluable optogenetic
tools for neuroscience as well as biomedical applications. Recently, MR-optogenetics …

Optogenetic control of lysosome function

NS Ilyinsky, SM Bukhalovich, DF Bagaeva… - bioRxiv, 2023 - biorxiv.org
Lysosome protective, metabolic, signaling functions are highly dependent on their pH. A lack
of tools of high spatial and temporal resolution for pH control is a bottleneck of lysosome …

[PDF][PDF] Stressed Lysosome: Theoretical Model of Late Endosomal and Lysosomal pH Regulationapplied to Single and Mixed Stress Conditions

S Nazarova, V Alekhin, V Pavlov, Y Semenov… - 2024 - preprints.org
Lysosomes are important organelles of eukaryotic cells required for autophagy, endocytosis,
protection against pathogens, maintenance of metabolic balance and cell signaling. A …

[图书][B] Application of an Optogenetic Tool to Increase Intracellular pH and Investigate pH-Dependent Cell Movement

CET Donahue - 2023 - search.proquest.com
Intracellular pH is tightly regulated (7.0-7.2) in normal cells, with transient changes in pHi
dynamics (7.4–7.6) being linked to a various normal cell behaviors including cytoskeleton …