Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases

Y Wang, J Hu, S Wu, JS Fleishman, Y Li, Y Xu… - … and Targeted Therapy, 2023 - nature.com
Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …

Natural products against Alzheimer's disease: Pharmaco-therapeutics and biotechnological interventions

A Dey, R Bhattacharya, A Mukherjee… - Biotechnology advances, 2017 - Elsevier
Alzheimer's disease (AD) is a severe, chronic and progressive neurodegenerative disease
associated with memory and cognition impairment ultimately leading to death. It is the …

Plant alkaloids as drug leads for Alzheimer's disease

YP Ng, TCT Or, NY Ip - Neurochemistry international, 2015 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative illness associated with dementia and is
most prevalent among the elderly population. Current medications can only treat symptoms …

[HTML][HTML] Role of plant derived alkaloids and their mechanism in neurodegenerative disorders

G Hussain, A Rasul, H Anwar, N Aziz… - … journal of biological …, 2018 - ncbi.nlm.nih.gov
Neurodegenerative diseases are conventionally demarcated as disorders with selective loss
of neurons. Conventional as well as newer molecules have been tested but they offer just …

Medicinal uses, phytochemistry and pharmacology of the genus Uncaria

Q Zhang, JJ Zhao, J Xu, F Feng, W Qu - Journal of Ethnopharmacology, 2015 - Elsevier
Abstract Ethnopharmacological relevance The genus Uncaria belongs to the family
Rubiaceae, which mainly distributed in tropical regions, such as Southeast Asia, Africa and …

Recent research progress of Uncaria spp. based on alkaloids: phytochemistry, pharmacology and structural chemistry

N Qin, X Lu, Y Liu, Y Qiao, W Qu, F Feng… - European Journal of …, 2021 - Elsevier
Medicinal plants are well-known in affording clinically useful agents, with rich medicinal
values by combining with disease targets through various mechanisms. Plant secondary …

The Main Alkaloids in Uncaria rhynchophylla and Their Anti-Alzheimer's Disease Mechanism Determined by a Network Pharmacology Approach

P Zeng, XM Wang, CY Ye, HF Su, Q Tian - International Journal of …, 2021 - mdpi.com
Alzheimer's disease (AD) is a growing concern in modern society, and effective drugs for its
treatment are lacking. Uncaria rhynchophylla (UR) and its main alkaloids have been studied …

Traditional Chinese medicine for anti-Alzheimer's disease: berberine and evodiamine from Evodia rutaecarpa

Z Fang, Y Tang, J Ying, C Tang, Q Wang - Chinese medicine, 2020 - Springer
Alzheimer's disease (AD) is one of the most common diseases in elderly people with a high
incidence of dementia at approximately 60–80%. The pathogenesis of AD was quite …

Protective role of Dihydromyricetin in Alzheimer's disease rat model associated with activating AMPK/SIRT1 signaling pathway

P Sun, JB Yin, LH Liu, J Guo, SH Wang… - Bioscience …, 2019 - portlandpress.com
The aim of the present study was to understand the possible role of the Dihydromyricetin
(DHM) in Alzheimer's disease (AD) rat model through regulation of the AMPK/SIRT1 …

Regulation of mitochondrial dysfunction induced cell apoptosis is a potential therapeutic strategy for herbal medicine to treat neurodegenerative diseases

RL Li, LY Wang, HX Duan, Q Zhang, X Guo… - Frontiers in …, 2022 - frontiersin.org
Neurodegenerative disease is a progressive neurodegeneration caused by genetic and
environmental factors. Alzheimer's disease (AD), Parkinson's disease (PD), and …