Today, Fmoc SPPS is the method of choice for peptide synthesis. Very‐high‐quality Fmoc
building blocks are available at low cost because of the economies of scale arising from …

The last decade has witnessed a renaissance of peptides as drugs. This progress, together
with advances in the structural behavior of peptides, has attracted the interest of the …

The central dogma of modern biology underscores the pivotal roles proteins play in diverse
biological processes, the study of which necessitates advanced methods to produce …

The site-selective modification of peptide backbones allows an outstanding fine-tuning of
peptide conformation, folding ability, and physico-chemical and biological properties …

Native chemical ligation combined with desulfurization has become a powerful strategy for
the chemical synthesis of proteins. Here we describe the use of a new thiol additive, methyl …

A growing theme in chemistry is the joining of multiple organic molecular building blocks to
create functional molecules. Diverse derivatizable structures—here termed “scaffolds” …

Polymerase chain reaction (PCR) has been a defining tool in modern biology. Towards
realizing mirror-image PCR, we have designed and chemically synthesized a mutant …

Extensive experimental and theoretical investigations are reported on the nature of
resonance‐assisted hydrogen bonding phenomenon (RAHB) and its influence on …

Coupling reagents play crucial roles in the iterative construction of amide bonds for the
synthesis of peptides and peptide‐based derivatives. The novel DIC/Oxyma condensation …

A backbone amide bond protecting group, 2‐hydroxy‐4‐methoxy‐5‐nitrobenzyl (Hmnb),
improved the synthesis of aggregation and aspartimide‐prone peptides. Introduction of …