[HTML][HTML] Cyclic dipeptides: The biological and structural landscape with special focus on the anti-cancer proline-based scaffold

J Bojarska, A Mieczkowski, ZM Ziora, M Skwarczynski… - Biomolecules, 2021 - mdpi.com
Cyclic dipeptides, also know as diketopiperazines (DKP), the simplest cyclic forms of
peptides widespread in nature, are unsurpassed in their structural and bio-functional …

Antimicrobial and biofilm inhibiting diketopiperazines

MP de Carvalho, WR Abraham - Current medicinal chemistry, 2012 - ingentaconnect.com
Diketopiperazines are the smallest cyclic peptides known. 90% of Gram-negative bacteria
produce diketopiperazines and they have also been isolated from Gram-positive bacteria …

Structural basis for nonribosomal peptide synthesis by an aminoacyl-tRNA synthetase paralog

L Bonnefond, T Arai, Y Sakaguchi… - Proceedings of the …, 2011 - National Acad Sciences
Cyclodipeptides are secondary metabolites biosynthesized by many bacteria and exhibit a
wide array of biological activities. Recently, a new class of small proteins, named …

[HTML][HTML] Research Progress of the Biosynthesis of Natural Bio-Antibacterial Agent Pulcherriminic Acid in Bacillus

S Yuan, X Yong, T Zhao, Y Li, J Liu - Molecules, 2020 - mdpi.com
Pulcherriminic acid is a cyclic dipeptide found mainly in Bacillus and yeast. Due to the ability
of pulcherriminic acid to chelate Fe3+ to produce reddish brown pulcherrimin …

Electronic Tuning of Mixed Quinoidal‐Aromatic Conjugated Polyelectrolytes: Direct Ionic Substitution on Polymer Main‐Chains

CL Anderson, N Dai, SJ Teat, B He… - Angewandte …, 2019 - Wiley Online Library
The synthesis of conjugated polymers with ionic substituents directly bound to their main
chain repeat units is a strategy for generating strongly electron‐accepting conjugated …

Common structural traits across pathogenic mutants of the human prion protein and their implications for familial prion diseases

G Rossetti, X Cong, R Caliandro, G Legname… - Journal of molecular …, 2011 - Elsevier
Human (Hu) familial prion diseases are associated with about 40 point mutations of the
gene coding for the prion protein (PrP). Most of the variants associated with these mutations …

Histamine H3 receptor antagonists with peptidomimetic (keto) piperazine structures to inhibit Aβ oligomerisation

M Falkenstein, D Reiner-Link, A Zivkovic… - Bioorganic & medicinal …, 2021 - Elsevier
Alzheimeŕs disease (AD) is the most prominent neurodegenerative disorder with high
medical need. Protein-protein-interactions (PPI) interactions have a critical role in AD where …

Small molecules that target protein misfolding

LK Gavrin, RA Denny, E Saiah - Journal of medicinal chemistry, 2012 - ACS Publications
Protein misfolding is a process in which proteins are unable to attain or maintain their
biologically active conformation. Factors contributing to protein misfolding include missense …

Designer Conjugation-Break Spacer That Boosts Charge Transport in Semiconducting Terpolymers

Y Qiang, R Xie, B He, C Liu, Q Zhou, Y Wang… - …, 2024 - ACS Publications
Conjugated polymers (CPs) are pivotal for high-mobility applications, typically avoiding
nonconjugated units due to their perceived negative impact on charge transport. Contrary to …

[HTML][HTML] Cyclodipeptides from metagenomic library of a Japanese marine sponge

R He, B Wang, T Wakimoto, M Wang, L Zhu… - Journal of the Brazilian …, 2013 - SciELO Brasil
Culture-independent metagenomics is an attractive and promising approach to explore
unique bioactive small molecules from marine sponges harboring uncultured symbiotic …