[HTML][HTML] Cyclic dipeptides: The biological and structural landscape with special focus on the anti-cancer proline-based scaffold
Cyclic dipeptides, also know as diketopiperazines (DKP), the simplest cyclic forms of
peptides widespread in nature, are unsurpassed in their structural and bio-functional …
peptides widespread in nature, are unsurpassed in their structural and bio-functional …
Antimicrobial and biofilm inhibiting diketopiperazines
MP de Carvalho, WR Abraham - Current medicinal chemistry, 2012 - ingentaconnect.com
Diketopiperazines are the smallest cyclic peptides known. 90% of Gram-negative bacteria
produce diketopiperazines and they have also been isolated from Gram-positive bacteria …
produce diketopiperazines and they have also been isolated from Gram-positive bacteria …
Structural basis for nonribosomal peptide synthesis by an aminoacyl-tRNA synthetase paralog
L Bonnefond, T Arai, Y Sakaguchi… - Proceedings of the …, 2011 - National Acad Sciences
Cyclodipeptides are secondary metabolites biosynthesized by many bacteria and exhibit a
wide array of biological activities. Recently, a new class of small proteins, named …
wide array of biological activities. Recently, a new class of small proteins, named …
[HTML][HTML] Research Progress of the Biosynthesis of Natural Bio-Antibacterial Agent Pulcherriminic Acid in Bacillus
S Yuan, X Yong, T Zhao, Y Li, J Liu - Molecules, 2020 - mdpi.com
Pulcherriminic acid is a cyclic dipeptide found mainly in Bacillus and yeast. Due to the ability
of pulcherriminic acid to chelate Fe3+ to produce reddish brown pulcherrimin …
of pulcherriminic acid to chelate Fe3+ to produce reddish brown pulcherrimin …
Electronic Tuning of Mixed Quinoidal‐Aromatic Conjugated Polyelectrolytes: Direct Ionic Substitution on Polymer Main‐Chains
CL Anderson, N Dai, SJ Teat, B He… - Angewandte …, 2019 - Wiley Online Library
The synthesis of conjugated polymers with ionic substituents directly bound to their main
chain repeat units is a strategy for generating strongly electron‐accepting conjugated …
chain repeat units is a strategy for generating strongly electron‐accepting conjugated …
Common structural traits across pathogenic mutants of the human prion protein and their implications for familial prion diseases
Human (Hu) familial prion diseases are associated with about 40 point mutations of the
gene coding for the prion protein (PrP). Most of the variants associated with these mutations …
gene coding for the prion protein (PrP). Most of the variants associated with these mutations …
Histamine H3 receptor antagonists with peptidomimetic (keto) piperazine structures to inhibit Aβ oligomerisation
M Falkenstein, D Reiner-Link, A Zivkovic… - Bioorganic & medicinal …, 2021 - Elsevier
Alzheimeŕs disease (AD) is the most prominent neurodegenerative disorder with high
medical need. Protein-protein-interactions (PPI) interactions have a critical role in AD where …
medical need. Protein-protein-interactions (PPI) interactions have a critical role in AD where …
Small molecules that target protein misfolding
LK Gavrin, RA Denny, E Saiah - Journal of medicinal chemistry, 2012 - ACS Publications
Protein misfolding is a process in which proteins are unable to attain or maintain their
biologically active conformation. Factors contributing to protein misfolding include missense …
biologically active conformation. Factors contributing to protein misfolding include missense …
Designer Conjugation-Break Spacer That Boosts Charge Transport in Semiconducting Terpolymers
Conjugated polymers (CPs) are pivotal for high-mobility applications, typically avoiding
nonconjugated units due to their perceived negative impact on charge transport. Contrary to …
nonconjugated units due to their perceived negative impact on charge transport. Contrary to …
[HTML][HTML] Cyclodipeptides from metagenomic library of a Japanese marine sponge
Culture-independent metagenomics is an attractive and promising approach to explore
unique bioactive small molecules from marine sponges harboring uncultured symbiotic …
unique bioactive small molecules from marine sponges harboring uncultured symbiotic …