Type 1 diabetes is an autoimmune disease caused by the immune-mediated destruction of
pancreatic β cells that results in lifelong absolute insulin deficiency. For nearly a century …

Type 1 diabetes mellitus (T1DM) results from the destruction of pancreatic β-cells that is
mediated by the immune system. Multiple genetic and environmental factors found in …

Narcolepsy is a chronic sleep disorder caused by the loss of neurons that produce
hypocretin. The close association with HLA-DQB1* 06: 02, evidence for immune …

Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic β
cells. Individuals with type 1 diabetes are reliant on insulin for survival. Despite enhanced …

T cell–mediated destruction of insulin-producing β cells in the pancreas causes type 1
diabetes (T1D). CD4 T cell responses play a central role in β cell destruction, but the identity …

Type 1 diabetes (T1D) results from destruction of pancreatic beta cells by T cells of the
immune system. Despite improvements in insulin analogs and continuous blood glucose …

A major therapeutic goal for type 1 diabetes (T1D) is to induce autoantigen-specific
tolerance of T cells. This could suppress autoimmunity in those at risk for the development of …

Cytotoxic CD8 T lymphocytes play a central role in the tissue destruction of many
autoimmune disorders. In type 1 diabetes (T1D), insulin and its precursor preproinsulin are …

The field of tissue engineering has advanced over the past decade, but the largest impact on
human health should be achieved with the transition of engineered solid organs to the clinic …

With the conceptual advance about four decades ago that type 1 diabetes represents an
autoimmune disease, hope arose that immune-based therapies would soon emerge to …