“In-Water” Three-Component One-Pot Reaction for the Facile Synthesis of Densely Functionalized 2,3-Dihydro-1H-pyrrol-2-ols and Mechanistic Insight
An environmentally friendly multicomponent reaction strategy for the synthesis of functionally
rich all-carbon substituted 2, 3-dihydro-1 H-pyrrol-2-ols “in-water” at room temperature has …
rich all-carbon substituted 2, 3-dihydro-1 H-pyrrol-2-ols “in-water” at room temperature has …
Profiling Cellular Morphological Changes Induced by Dual‐Targeting PROTACs of Aurora Kinase and RNA‐Binding Protein YTHDF2
GL Goebel, N Giannino, P Lampe, X Qiu… - …, 2024 - Wiley Online Library
Proteolysis targeting chimeras (PROTACs) are new chemical modalities that degrade
proteins of interest, including established kinase targets and emerging RNA‐binding …
proteins of interest, including established kinase targets and emerging RNA‐binding …
[HTML][HTML] Application of the Rumsfeld matrix to anticancer natural product target discovery
C Bailly - Pharmacological Research-Reports, 2024 - Elsevier
For a long time, natural products (NP) contribute to the treatment of human pathologies,
notably to cancer treatment with microbial and plant-derived products. The mechanism of …
notably to cancer treatment with microbial and plant-derived products. The mechanism of …
NIMO: A Natural Product-Inspired Molecular Generative Model Based on Conditional Transformer
Natural products (NPs) have diverse biological activity and significant medicinal value. The
structural diversity of NPs is the mainstay of drug discovery. Expanding the chemical space …
structural diversity of NPs is the mainstay of drug discovery. Expanding the chemical space …
Synthesis, Identification, and Chemoenzymatic Functionalisation of Inhibitors of Sterol Transport Proteins
FS Bro - 2024 - orbit.dtu.dk
Sterol transport proteins (STPs) mediate intracellular sterol transport, organelle contact sites,
and lipid metabolism. Their mis-regulation has been associated with lipid storage disorders …
and lipid metabolism. Their mis-regulation has been associated with lipid storage disorders …
Identification of a privileged scaffold for inhibition of sterol transport proteins through the synthesis and ring distortion of diverse, pseudo-natural products
FS Bro, L Depta, N Dekker, H Bryce-Rogers… - 2024 - chemrxiv.org
Sterol transport proteins mediate intracellular sterol transport, organelle contact sites, and
lipid metabolism. Despite their importance, the similarities in their sterol-binding domains …
lipid metabolism. Despite their importance, the similarities in their sterol-binding domains …