Significant advances in our understanding of the in vivo functions of human cells and tissues
and the human immune system have resulted from the development of'humanized'mouse …

Despite its complexity, blood is probably the best understood developmental system, largely
due to seminal experimentation in the mouse. Clinically, hematopoietic stem cell (HSC) …

The study of human macrophages and their ontogeny is an important unresolved issue.
Here, we use a humanized mouse model expressing human cytokines to dissect the …

Mice repopulated with human hematopoietic cells are a powerful tool for the study of human
hematopoiesis and immune function in vivo. However, existing humanized mouse models …

Macrophages are tissue‐resident myeloid cells with essential roles in host defense, tissue
repair, and organ homeostasis. The lung harbors a large number of macrophages that …

Humanized mouse models that have received human cells or tissue transplants are
extremely useful in basic and applied human disease research. Highly immunodeficient …

To directly study complex human hemato-lymphoid system physiology and respective
system-associated diseases in vivo, human-to-mouse xenotransplantation models for …

Xenotransplantation models represent powerful tools for the investigation of healthy and
malignant human hematopoiesis. However, current models do not fully mimic the …

Immune cell differentiation is critical for adequate tissue-specific immune responses to
occur. Here, we studied differentiation of human uterine natural killer cells (uNK cells) …

The mononuclear phagocyte system (MPS) comprises monocytes, macrophages and
dendritic cells. Tissue phagocytes share several cell surface markers, phagocytic capability …