Humans and our ancestors have evolved since the most ancient times with a commensal
microbiota. The conservation of indicator species in a niche-specific manner across all of the …

Vaccination against Haemophilus influenzae type b (Hib) diseases began a quarter of a
century ago with a polysaccharide vaccine; this vaccine was followed by four different …

Background Before the introduction of the conjugate vaccines, Haemophilus influenzae type
b was the major cause of bacterial meningitis in the United States, and meningitis was …

Background Haemophilus influenzae type b (Hib) is a leading cause of childhood bacterial
meningitis, pneumonia, and other serious infections. Hib disease can be almost completely …

The theory proposed is that a critical level of specific serum IgG is sufficient to confer
protection against infectious diseases by inactivating the inoculum of the pathogen. This …

Microbial targets for protective humoral immunity are typically surface-localized proteins and
contain common sequence motifs related to their secretion or surface binding. Exploiting the …

Haemophilus influenzae type b (Hib) is one of the leading causes of invasive bacterial
infection in young children worldwide. During childhood, acquisition of antibody directed …

Background The aim of this double-blind randomised vaccine-controlled trial was to assess
the efficacy of a conjugate vaccine composed of Shigella sonnei O-specific polysaccharide …

Objective: To assess the direct and indirect effects of the introduction of routine use of
pneumococcal conjugate vaccine in infants and toddlers at risk for invasive disease caused …

Children 12-18 months old were randomized to receive one dose of a conjugate heptavalent
pneumococcal vaccine, two doses of the same vaccine, or one dose of a 23-valent native …