Co-evolution techniques were originally conceived to assist in protein structure prediction by
inferring pairs of residues that share spatial proximity. However, the functional relationships …

Evolutionary pressure on residue interactions, intramolecular or intermolecular, that are
important for protein structure or function can lead to covariance between the two positions …

Background: Recent strides in computational structural biology have opened up an
opportunity to understand previously uncharacterised proteins. The under-representation of …

Motivation Domain boundary prediction is one of the most important problems in the study of
protein structure and function. Many sequence-based domain boundary prediction methods …

The structure of human Methylenetetrahydrofolate Reductase (MTHFR) is not known either
by NMR or by X-ray methods. Phosphorylation seems to play an important role in the …

Bacterial competence, which can be natural or induced, allows the uptake of exogenous
double stranded DNA (dsDNA) into a competent bacterium. This process is known as …

Recent work has led to a substantial improvement in the accuracy of predictions of contacts
between amino acids using evolutionary information derived from multiple sequence …

The prospect of identifying contacts in protein structures purely from aligned protein
sequences has lured researchers for a long time, but progress has been modest until …

Covariance-based predictions of residue contacts and inter-residue distances are an
increasingly popular data type in protein bioinformatics. Here we present ConPlot, a web …

For many protein families, the deluge of new sequence information together with new
statistical protocols now allow the accurate prediction of contacting residues from sequence …