Oxygen deprivation or hypoxia characterizes a number of serious pathological conditions
and elicits a number of adaptive changes that are mainly mediated at the transcriptional …

Hypoxia is a feature of most tumours, albeit with variable incidence and severity within a
given patient population. It is a negative prognostic and predictive factor owing to its multiple …

As oxygen is essential for many metabolic pathways, tumour hypoxia may impair cancer cell
proliferation,,–. However, the limiting metabolites for proliferation under hypoxia and in …

Clear cell renal cell carcinoma (ccRCC) is the most common kidney cancer and has very few
mutations that are shared between different patients. To better understand the intratumoral …

Resistance towards chemotherapy, either primary or acquired, represents a major obstacle
in clinical oncology. Three basic categories underlie most cases of chemotherapy failure …

Simple Summary The term hypoxia is used to describe biological situations where
insufficient levels of oxygen exist. Hypoxia and hypoxic states can occur in a range of …

Glioma growth and progression depend on a specialized subpopulation of tumour cells,
termed tumour stem cells. Thus, tumour stem cells represent a critical therapeutic target, but …

Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer due to its highly
invasive nature that impedes the surgical removal of all tumor cells, making relapse …

IgG antibodies cause inflammation and organ damage in autoimmune diseases such as
systemic lupus erythematosus (SLE). We investigated the metabolic profile of macrophages …

Increasing evidence from epidemiological, preclinical and clinical studies suggests that
dysregulated inflammatory response plays a pivotal role in a multitude of chronic ailments …