Excess body weight is frequently associated with low-grade inflammation. Evidence
indicates a relationship between obesity and cancer, as well as with other diseases, such as …

MicroRNAs (miRNAs) are a class of small, well-conserved noncoding RNAs that regulate
gene expression post-transcriptionally. They have been demonstrated to regulate a lot of …

First seen as a fat-storage tissue, the adipose tissue is considered as a critical player in the
endocrine system. Precisely, adipose tissue can produce an array of bioactive factors …

Leptin, produced and secreted by white adipose tissue, plays a critical role in regulating
body weight, food intake, and energy metabolism. Recently, several studies have identified …

There is accumulating evidence from epidemiological studies that changes in body weight
are associated with Alzheimer's disease (AD) from mid-life obesity increasing the risk of …

miR-132 and miR-212 are structurally related microRNAs that have been found to exert
powerful modulatory effects within the central nervous system (CNS). Notably, these …

Calcium is a ubiquitous second messenger that is indispensable in regulating
neurotransmission and memory formation. A precise intracellular calcium level is achieved …

Consumption of a high-fat diet has long been known to increase risk for obesity, diabetes,
and the metabolic syndrome. Further evidence strongly suggests that these same metabolic …

Noncoding polymorphisms in the fat mass and obesity-associated (FTO) gene represent
common alleles that are strongly associated with effects on food intake and adiposity in …

Regular exercise and dietary supplements with antioxidants each have the potential to
improve cognitive function and attenuate cognitive decline, and, in some cases, they …