Management of bleeding and coagulopathy following major trauma: an updated European guideline

DR Spahn, B Bouillon, V Cerny, TJ Coats, J Duranteau… - Critical care, 2013 - Springer
Introduction Evidence-based recommendations are needed to guide the acute management
of the bleeding trauma patient. When these recommendations are implemented patient …

[PDF][PDF] Fluid resuscitation for hemorrhagic shock in tactical combat casualty care: TCCC guidelines change 14-01-2 June 2014

FK Butler, JB Holcomb, MA Schreiber… - J Spec Oper …, 2014 - books.allogy.com
Background New concepts in resuscitation from hemorrhagic shock (or renewed interest in
older concepts) have been emerging in recent years. A report from 1993 noted that initial …

The European guideline on management of major bleeding and coagulopathy following trauma

DR Spahn, B Bouillon, V Cerny, J Duranteau… - Critical care, 2019 - Springer
Background Severe traumatic injury continues to present challenges to healthcare systems
around the world, and post-traumatic bleeding remains a leading cause of potentially …

The European guideline on management of major bleeding and coagulopathy following trauma

R Rossaint, B Bouillon, V Cerny, TJ Coats, J Duranteau… - Critical care, 2016 - Springer
Background Severe trauma continues to represent a global public health issue and mortality
and morbidity in trauma patients remains substantial. A number of initiatives have aimed to …

Transfusion of plasma, platelets, and red blood cells in a 1: 1: 1 vs a 1: 1: 2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial

JB Holcomb, BC Tilley, S Baraniuk, EE Fox, CE Wade… - Jama, 2015 - jamanetwork.com
Importance Severely injured patients experiencing hemorrhagic shock often require massive
transfusion. Earlier transfusion with higher blood product ratios (plasma, platelets, and red …

Damage control resuscitation in patients with severe traumatic hemorrhage: a practice management guideline from the Eastern Association for the Surgery of Trauma

JW Cannon, MA Khan, AS Raja… - Journal of Trauma …, 2017 - journals.lww.com
Background The resuscitation of severely injured bleeding patients has evolved into a multi-
modal strategy termed damage control resuscitation (DCR). This guideline evaluates …

Resuscitation and transfusion principles for traumatic hemorrhagic shock

PC Spinella, JB Holcomb - Blood reviews, 2009 - Elsevier
The transfusion approach to massive hemorrhage has continually evolved since it began in
the early 1900s. It started with fresh whole blood and currently consists of virtually exclusive …

Primary hemostatic capacity of whole blood: a comprehensive analysis of pathogen reduction and refrigeration effects over time

HF Pidcoke, SJ McFaul, AK Ramasubramanian… - …, 2013 - Wiley Online Library
Background Whole blood (WB) has been used in combat since World War I as it is readily
available and replaces every element of shed blood. Component therapy has become …

Increased platelet: RBC ratios are associated with improved survival after massive transfusion

JB Holcomb, LA Zarzabal, JE Michalek… - Journal of Trauma …, 2011 - journals.lww.com
Background: Several recent military and civilian trauma studies demonstrate that improved
outcomes are associated with early and increased use of plasma-based resuscitation …

Ten-year analysis of transfusion in Operation Iraqi Freedom and Operation Enduring Freedom: increased plasma and platelet use correlates with improved survival

HF Pidcoke, JK Aden, AG Mora… - Journal of Trauma …, 2012 - journals.lww.com
BACKGROUND The Joint Theater Trauma Registry database, begun early in Operation Iraqi
Freedom and Operation Enduring Freedom, created a comprehensive repository of …