Atopic dermatitis (AD) is a chronic inflammatory skin condition that affects diverse ethnic
groups with varying prevalence. Despite a predominance of studies in individuals of …

Atopic dermatitis (AD) is driven by a complex gene–environment interaction. Many of the risk
factors and genetic underpinning previously observed for pediatric AD may not apply to …

Atopic dermatitis (AD) is a chronic inflammatory skin disease with specific immune and
inflammatory mechanisms. Atopy is among the major features of the diagnosis criteria for AD …

This best-selling resource has a worldwide reputation as the leader in its field. Focusing on
human immunology and biology, while also reporting on scientific experimentation and …

A genetic basis for atopic dermatitis (AD) has long been recognized. Historic documents
allude to family history of disease as a risk factor. Before characterization of the human …

There is an increasing incidence of atopic diseases (asthma, allergic rhinitis and atopic
dermatitis) in humans, especially in developed countries. Although there is a genetic …

Mast cells (MCs) are traditionally thought of as a nuisance for its host, for example, by
causing many of the symptoms associated with allergic reactions. In addition, recent …

Asthma and atopy show epidemiological association and are biologically linked by T-helper
type 2 (Th2) cytokine-driven inflammatory mechanisms. IL-4 operates through the IL-4 …

Atopic dermatitis (AD) is a pruritic inflammatory skin disease associated with a personal or
family history of allergy. The prevalence of AD is on the rise and estimated at∼ 17% in the …

E (IgE) production and leads to the clinical disorders of asthma, eczema and rhinitis1.
Interleukin 4 (IL4) is a pleiotropic cytokine which plays a crucial role in IgE-dependent atopic …