In situ tissue regeneration harnesses the body's regenerative potential to control cell
functions for tissue repair. The design of biomaterials for in situ tissue engineering requires …

Bone tissue has a remarkable ability to regenerate and heal itself. However, large bone
defects and complex fractures still present a significant challenge to the medical community …

Considering the complicated and irregular anatomical structure of root canal systems,
injectable microspheres have received considerable attention as cell carriers in endodontic …

Hydrogels are polymeric materials distinguished by high water content and diverse physical
properties. They can be engineered to resemble the extracellular environment of the body's …

Stem cell therapies are limited by poor cell survival and engraftment. A hurdle to the use of
materials for cell delivery is the lack of understanding of material properties that govern …

The extracellular matrix (ECM) is synthesized and secreted by embryonic cells beginning at
the earliest stages of development. Our understanding of ECM composition, structure and …

Growth factors (GFs) are critical in tissue repair, but their translation to clinical use has been
modest. Physiologically, GF interactions with extracellular matrix (ECM) components …

One of the recent paradigm shifts in stem cell biology has been the discovery that stem cells
can begin to differentiate into mature tissue cells when exposed to intrinsic properties of the …

The bioactivity of biomaterials is closely related to cell response in contact with them.
However, shortly after their insertion, materials are soon covered with proteins that constitute …

Although growth factors naturally exert their morphogenetic influences within the context of
the extracellular matrix microenvironment, the interactions among growth factors, their …