Atherosclerosis is a chronic inflammatory disease, in which the immune system has a
prominent role in its development and progression. Inflammation-induced endothelial …

Recent advances have greatly improved our understanding of the molecular mechanisms
behind atherosclerosis pathogenesis. However, there is still a need to systematize this data …

Research showing that microRNAs (miRNAs) are versatile regulators of gene expression
has instigated tremendous interest in cardiovascular research. The overwhelming majority of …

Hypertension is a global health problem, with> 1.3 billion individuals with high blood
pressure worldwide. In this Review, we present an inflammatory paradigm for hypertension …

Pain involves neuroimmune crosstalk, but the mechanisms of this remain unclear. Here we
showed that the splenic T helper 2 (TH2) immune cell response is differentially regulated in …

Ischemic heart disease is the greatest health burden and most frequent cause of death
worldwide. Myocardial ischemia/reperfusion is the pathophysiological substrate of ischemic …

Brown adipose tissue (BAT)-mediated thermogenesis declines with age. However, the
underlying mechanism remains unclear. Here we reveal that bone marrow-derived pro …

Arteriosclerosis, which appears as a hardened and narrowed artery with plaque buildup, is
the primary cause of various cardiovascular diseases such as stroke. Arteriosclerosis is …

Hypertensive heart disease constitutes functional and structural dysfunction and
pathogenesis occurring primarily in the left ventricle, the left atrium and the coronary arteries …

This review based on the ESC William Harvey Lecture in Basic Science 2022 highlights
recent experimental and translational progress on the therapeutic targeting of the …