The ability to introduce DNA sequences (eg, genes) of interest into the germline genome
has rendered the mouse a powerful and indispensable experimental model in fundamental …

Multiple sclerosis (MS) is an inflammatory and demyelinating condition of the CNS,
characterized by perivascular infiltrates composed largely of T lymphocytes and …

A classic feature of apoptotic cells is the cell-surface exposure of phosphatidylserine
(PtdSer) as an “eat me” signal for engulfment. We show that the Xk-family protein Xkr8 …

Conditional mutagenesis in mice has recently been made possible through the combination
of gene targeting techniques and site–directed mutagenesis, using the bacteriophage P1 …

We have produced a mouse strain in which the deletion of the NMDAR1 gene is restricted to
the CA1 pyramidal cells of the hippocampus by using a new and general method that allows …

The WD40-containing E3 ubiquitin ligase RFWD3 has been recently linked to the repair of
DNA damage by homologous recombination (HR). Here we have shown that an RFWD3 …

OX2 (CD200) is a broadly expressed membrane glycoprotein, shown here to be important
for regulation of the macrophage lineage. In mice lacking CD200, macrophage lineage cells …

A new system for lineage ablation is based on transgenic expression of a diphtheria toxin
receptor (DTR) in mouse cells and application of diphtheria toxin (DT). To streamline this …

Marginal zone (MZ) B cells produce broad-spectrum antibodies that protect against infection
early in life. In some instances, antibody production requires MZ B cells to display pathogen …

Little is known about metabolic regulation in stem cells and how this modulates tissue
regeneration or tumour suppression. We studied the Lkb1 tumour suppressor and its …