Alzheimer's disease pathogenesis: Role of autophagy and mitophagy focusing in microglia

M Eshraghi, A Adlimoghaddam… - International Journal of …, 2021 - mdpi.com
Alzheimer's disease (AD) is a debilitating neurological disorder, and currently, there is no
cure for it. Several pathologic alterations have been described in the brain of AD patients …

Role of Nrf2 in synaptic plasticity and memory in Alzheimer's disease

DA Davies, A Adlimoghaddam, BC Albensi - Cells, 2021 - mdpi.com
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important transcription factor that
reduces oxidative stress. When reactive oxygen species (ROS) or reactive nitrogen species …

Chemicals used for the induction of Alzheimer's disease-like cognitive dysfunctions in rodents

O Mahdi, MTH Baharuldin, NHM Nor… - Biomedical Research …, 2019 - biomedpress.org
Alzheimer's disease (AD) is the most frequent and multifactorial form of dementia,
characterised by multiple cognitive impairments and personality changes. Different methods …

Do serum GDNF levels correlate with severity of Alzheimer's disease?

M Sharif, M Noroozian, F Hashemian - Neurological Sciences, 2021 - Springer
Introduction A growing body of evidence that glial cell line–derived neurotrophic factor
(GDNF) levels are probably involved in pathogenesis and disease course of Alzheimer's …

Alzheimer's disease-related metabolic pattern in diverse forms of neurodegenerative diseases

A Lau, I Beheshti, M Modirrousta, TA Kolesar… - Diagnostics, 2021 - mdpi.com
Dementia is broadly characterized by cognitive and psychological dysfunction that
significantly impairs daily functioning. Dementia has many causes including Alzheimer's …

An exemplar pyramid feature extraction based Alzheimer disease classification method

HS Zaina, SB Belhaouari, T Stanko, V Gorovoy - IEEE Access, 2022 - ieeexplore.ieee.org
Dementia is a term used to describe a variety of symptoms related to cognitive impairment in
which Alzheimer disease represents 60%–70% of the cases. As of today, there is no cure for …

Age-and sex-associated alterations in hypothalamic mitochondrial bioenergetics and inflammatory-associated signaling in the 3xTg mouse model of Alzheimer's …

A Adlimoghaddam, KM Fontaine, BC Albensi - Biology of sex Differences, 2024 - Springer
Mitochondrial dysfunction and associated inflammatory signaling are pivotal in both aging
and in Alzheimer's disease (AD). Studies have also shown that hypothalamic function is …

Neuroscience20 (BRAIN20, SPINE20, and MENTAL20) health initiative: A global consortium addressing the human and economic burden of brain, spine, and mental …

K Morris, M Nami, JF Bolanos, MA Lobo… - Journal of …, 2021 - content.iospress.com
Neuroscience20 (BRAIN20, SPINE20, and MENTAL20) Health Initiative: A Global
Consortium Addressing the Human and Economic Burden of Brain, Spine, and Mental …

Race-and sex-based disparities in Alzheimer's disease clinical trial enrollment in the United States and Canada: an indigenous perspective

NL Olson, BC Albensi - Journal of Alzheimer's Disease …, 2020 - content.iospress.com
Randomized clinical trials (RCT) involve labor-intensive, highly regulated, and controlled
processes intended to transform scientific concepts into clinical outcomes. To be effective …

Explaining caregivers' perceptions of palliative care unmet needs in Iranian Alzheimer's patients: a qualitative study

H Ashrafizadeh, M Gheibizadeh, M Rassouli… - Frontiers in …, 2021 - frontiersin.org
Introduction: The needs of Alzheimer's patients are very complex and diverse and many of
them are considered unmet needs. Understanding and responding to the unmet and …