Dysbiosis of gut microbiota in promoting the development of colorectal cancer

S Zou, L Fang, MH Lee - Gastroenterology report, 2018 - academic.oup.com
Gastrointestinal microbiome, containing at least 100 trillion bacteria, resides in the mucosal
surface of human intestine. Recent studies show that perturbations in the microbiota may …

Towards microbial fermentation metabolites as markers for health benefits of prebiotics

KA Verbeke, AR Boobis, A Chiodini… - Nutrition research …, 2015 - cambridge.org
Available evidence on the bioactive, nutritional and putative detrimental properties of gut
microbial metabolites has been evaluated to support a more integrated view of how …

Gut microbiota in colorectal cancer: biological role and therapeutic opportunities

H Pandey, DWT Tang, SH Wong, D Lal - Cancers, 2023 - mdpi.com
Simple Summary Colorectal cancer (CRC) is the second-leading cause of cancer-related
deaths worldwide. In this review article, we examine the role of gut microbiota in the …

Role of SCFAs in gut microbiome and glycolysis for colorectal cancer therapy

G Wang, Y Yu, YZ Wang, JJ Wang… - Journal of cellular …, 2019 - Wiley Online Library
Increased risk of colorectal cancer (CRC) is associated with altered intestinal microbiota as
well as short‐chain fatty acids (SCFAs) reduction of output The energy source of colon cells …

Mitochondrial dysfunction in inflammatory bowel disease

EA Novak, KP Mollen - Frontiers in cell and developmental biology, 2015 - frontiersin.org
Inflammatory Bowel Disease (IBD) represents a group of idiopathic disorders characterized
by chronic or recurring inflammation of the gastrointestinal tract. While the exact etiology of …

A review of the potential mechanisms for the lowering of colorectal oncogenesis by butyrate

KYC Fung, L Cosgrove, T Lockett, R Head… - British Journal of …, 2012 - cambridge.org
Colorectal cancer (CRC) is a leading cause of preventable cancer deaths worldwide, with
dietary factors being recognised as key risk modifiers. Foods containing dietary fibre are …

Effects of intestinal microbial–elaborated butyrate on oncogenic signaling pathways

J Chen, KN Zhao, L Vitetta - Nutrients, 2019 - mdpi.com
The intestinal microbiota is well known to have multiple benefits on human health, including
cancer prevention and treatment. The effects are partially mediated by microbiota-produced …

[HTML][HTML] Butyrate induces ROS-mediated apoptosis by modulating miR-22/SIRT-1 pathway in hepatic cancer cells

K Pant, AK Yadav, P Gupta, R Islam, A Saraya… - Redox Biology, 2017 - Elsevier
Butyrate is one of the short chain fatty acids, produced by the gut microbiota during
anaerobic fermentation of dietary fibres. It has been shown that it can inhibit tumor …

From microbe to man: the role of microbial short chain fatty acid metabolites in host cell biology

N Natarajan, JL Pluznick - American Journal of Physiology …, 2014 - journals.physiology.org
Recent studies have highlighted a myriad of ways in which the activity and composition of
the gut microbiota can affect the host organism. A primary way in which the gut microbiota …

[HTML][HTML] Gut microbiota in renal physiology: focus on short-chain fatty acids and their receptors

JL Pluznick - Kidney international, 2016 - Elsevier
A number of recent studies have begun to explore a new and exciting area: the interaction
between the gut microbiome and renal physiology. In particular, multiple studies have …