Polyphenols are the most important phytochemicals in our diets and have received great
attention due to their broad benefits for human health by suppressing oxidative stress and …

Interest in 3D printing for pharmaceutical applications has increased in recent years.
Compared to other 3D printing techniques, hot melt extrusion (HME)-based fused deposition …

A significant proportion of recently approved drug molecules possess poor aqueous
solubility which further restrains their desired bioavailability. Poor aqueous solubility of these …

The pharmaceutical development of amorphous solid dispersions (ASDs) by hot-melt
extrusion (HME) is briefly reviewed. A systematic step-by-step approach is presented, where …

Hot-melt extrusion (HME) has emerged as a pioneering manufacturing technology for
pharmaceutical industries, and the utilization is overgrowing due to its unit operation, cost …

Oral delivery has become the route of choice among all other types of drug administrations.
However, typical chronic disease drugs are often poorly water-soluble, have low dissolution …

Introduction Rapid advances in bioengineering enable the use of complex proteins as
therapeutic agents to treat diseases. Compared with conventional small molecule drugs …

Introduction: Interest in hot-melt extrusion (HME) technology for novel applications is
growing day by day, which is evident from several hundred publications within the last 5 …

Solid lipid-based formulations (sLBFs) have the potential to increase the oral bioavailability
of drugs with poor solubility in water, while counteracting some of the disadvantages of …

Introduction: Currently, hot melt extrusion (HME) is a promising technology in the
pharmaceutical industry, as evidenced by its application to manufacture various FDA …