Engineering therapeutical extracellular vesicles for clinical translation

Y Ma, S Dong, AJ Grippin, L Teng, AS Lee… - Trends in …, 2024 - cell.com
Cell-based therapies are revolutionizing medicine by replacing or modifying dysfunctional
cells with healthy cells or engineered derivatives, offering disease reversal and cure. One …

[HTML][HTML] Microfluidics for personalized drug delivery

SE Alavi, S Alharthi, SF Alavi, SZ Alavi, GE Zahra… - Drug Discovery …, 2024 - Elsevier
This review highlights the transformative impact of microfluidic technology on personalized
drug delivery. Microfluidics addresses issues in traditional drug synthesis, providing precise …

Dacarbazine-primed carbon quantum dots coated with breast cancer cell-derived exosomes for improved breast cancer therapy

P Tiwari, RP Shukla, K Yadav, N Singh… - Journal of Controlled …, 2024 - Elsevier
Imprecise targeting of chemotherapeutic drugs often leads to severe toxicity during breast
cancer therapy. To address this issue, we have devised a strategy to load dacarbazine (DC) …

A fractional-order model for optimizing combination therapy in heterogeneous lung cancer: integrating immunotherapy and targeted therapy to minimize side effects

D Amilo, C Izuchukwu, K Sadri, HR Yao, E Hincal… - Scientific Reports, 2024 - nature.com
This research presents a novel approach to address the complexities of heterogeneous lung
cancer dynamics through the development of a Fractional-Order Model. Focusing on the …

Surface-modified lyotropic crystalline nanoconstructs bearing doxorubicin and buparvaquone target sigma receptors through pH-sensitive charge conversion to …

N Singh, D Marwaha, S Gautam, N Rai… - …, 2023 - ACS Publications
In the current study, we aimed to develop lyotropic crystalline nanoconstructs (LCNs) based
on poly (l-glutamic acid)(PLG) with a two-tier strategy. The first objective was to confer pH …

Exploring nanocarriers as innovative materials for advanced drug delivery strategies in onco-immunotherapies

P Tiwari, RP Shukla, K Yadav, D Panwar… - Journal of Molecular …, 2024 - Elsevier
In recent years, Onco-immunotherapies (OIMTs) have been shown to be a potential therapy
option for cancer. Several immunotherapies have received regulatory approval, while many …

Alendronate-functionalized porous nano-crystalsomes mitigate osteolysis and consequent inhibition of tumor growth in a tibia-induced metastasis model

RP Shukla, P Tiwari, A Sardar, S Urandur… - Journal of Controlled …, 2024 - Elsevier
Bone is one of the most prevalent sites of metastases in various epithelial malignancies,
including breast cancer and this metastasis to bone often leads to severe skeletal …

[HTML][HTML] A complex molecular landscape to drug delivery concept for achieving precise therapy in psoriasis

K Yadav, KK Sahu, R Yadav, W Raza, S Minz… - Medicine in Drug …, 2024 - Elsevier
Psoriasis is a chronic autoimmune disorder that has a major effect on the quality of life for
millions of people throughout the world. The pathogenesis of psoriasis has revealed intricate …

Recent updates on ocular disease management with ophthalmic ointments

AC Bisen, A Dubey, S Agrawal, A Biswas… - Therapeutic …, 2024 - Taylor & Francis
Ophthalmic diseases can result in permanent vision loss and blindness. Convenient topical
and systemic treatments are preferred to address these sight-threatening conditions …

Extracellular vesicles-powered immunotherapy: Unleashing the potential for safer and more effective cancer treatment

P Tiwari, K Yadav, RP Shukla, AK Bakshi… - Archives of Biochemistry …, 2024 - Elsevier
Cancer treatment has seen significant advancements with the introduction of Onco-
immunotherapies (OIMTs). Although some of these therapies have received approval for …