Intrinsic coupling constitutes a key feature of ongoing brain activity, which exhibits rich
spatiotemporal patterning and contains information that influences cognitive processing. We …

Biomarkers in whichever modality are tremendously important in diagnosing of disease,
tracking disease progression and clinical trials. This applies in particular for disorders with a …

Objective The benefit of deep brain stimulation (DBS) for Parkinson disease (PD) may
depend on connectivity between the stimulation site and other brain regions, but which …

Parkinson's disease (PD) is characterised by the emergence of beta frequency oscillatory
synchronisation across the cortico-basal-ganglia circuit. The relationship between the …

Objectives Firstly, to identify subthalamic region stimulation clusters that predict maximum
improvement in rigidity, bradykinesia and tremor, or emergence of side-effects; and …

Tremor in Parkinson's disease has several mysterious features. Clinically, tremor is seen in
only three out of four patients with Parkinson's disease, and tremor-dominant patients …

Chronic dopamine depletion in Parkinson's disease leads to progressive motor and
cognitive impairment, which is associated with the emergence of characteristic patterns of …

Despite advances towards understanding the molecular pathophysiology of the
neurodegenerative dementias, the mechanisms linking molecular changes to …

Movement disorders can occur as primary (idiopathic) or genetic disease, as a manifestation
of an underlying neurodegenerative disorder, or secondary to a wide range of neurological …

Depleted of dopamine, the dynamics of the parkinsonian brain impact on both 'action'and
'resting'motor behaviour. Deep brain stimulation has become an established means of …