Mechanisms of podocyte injury and implications for diabetic nephropathy
F Barutta, S Bellini, G Gruden - Clinical Science, 2022 - portlandpress.com
Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies,
including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and …
including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and …
The evolving complexity of the podocyte cytoskeleton
C Schell, TB Huber - Journal of the American Society of …, 2017 - journals.lww.com
Podocytes exhibit a unique cytoskeletal architecture that is fundamentally linked to their
function in maintaining the kidney filtration barrier. The cytoskeleton regulates podocyte …
function in maintaining the kidney filtration barrier. The cytoskeleton regulates podocyte …
[HTML][HTML] MicroRNA-27a promotes podocyte injury via PPARγ-mediated β-catenin activation in diabetic nephropathy
Z Zhou, J Wan, X Hou, J Geng, X Li, X Bai - Cell death & disease, 2017 - nature.com
Podocyte injury has a pivotal role in the pathogenesis of diabetic nephropathy (DN).
MicroRNA-27a (miR-27a), peroxisome proliferator-activated receptor γ (PPARγ) and β …
MicroRNA-27a (miR-27a), peroxisome proliferator-activated receptor γ (PPARγ) and β …
Advances in fluorescence microscopy techniques to study kidney function
Fluorescence microscopy, in particular immunofluorescence microscopy, has been used
extensively for the assessment of kidney function and pathology for both research and …
extensively for the assessment of kidney function and pathology for both research and …
New insights into podocyte biology in glomerular health and disease
S Assady, N Wanner, KL Skorecki… - Journal of the American …, 2017 - journals.lww.com
Podocyte and glomerular research is center stage for the development of improved
preventive and therapeutic strategies for chronic progressive kidney diseases. Held April 3 …
preventive and therapeutic strategies for chronic progressive kidney diseases. Held April 3 …
[HTML][HTML] Catalpol ameliorates podocyte injury by stabilizing cytoskeleton and enhancing autophagy in diabetic nephropathy
Y Chen, Q Liu, Z Shan, W Mi, Y Zhao, M Li… - Frontiers in …, 2019 - frontiersin.org
Catalpol, an iridoid glycoside extracted from Rehmannia glutinosa, has been found to
ameliorate diabetic nephropathy (DN), but the mechanism has not been clarified. Podocyte …
ameliorate diabetic nephropathy (DN), but the mechanism has not been clarified. Podocyte …
Synaptopodin is dispensable for normal podocyte homeostasis but is protective in the context of acute podocyte injury
Background Synaptopodin (Synpo) is an actin-associated protein in podocytes and dendritic
spines. Many functions in regulating the actin cytoskeleton via RhoA and other pathways …
spines. Many functions in regulating the actin cytoskeleton via RhoA and other pathways …
[HTML][HTML] Proteinuric kidney diseases: a podocyte's slit diaphragm and cytoskeleton approach
SMW Yu, P Nissaisorakarn, I Husain, B Jim - Frontiers in Medicine, 2018 - frontiersin.org
Proteinuric kidney diseases are a group of disorders with diverse pathological mechanisms
associated with significant losses of protein in the urine. The glomerular filtration barrier …
associated with significant losses of protein in the urine. The glomerular filtration barrier …
Stressed podocytes—mechanical forces, sensors, signaling and response
K Endlich, F Kliewe, N Endlich - Pflügers Archiv-European Journal of …, 2017 - Springer
Increased glomerular capillary pressure (glomerular hypertension) and increased
glomerular filtration rate (glomerular hyperfiltration) have been proven to cause …
glomerular filtration rate (glomerular hyperfiltration) have been proven to cause …
Dissection of glomerular transcriptional profile in patients with diabetic nephropathy: SRGAP2a protects podocyte structure and function
Y Pan, S Jiang, Q Hou, D Qiu, J Shi, L Wang, Z Chen… - Diabetes, 2018 - Am Diabetes Assoc
Podocytes play a pivotal role in maintaining glomerular filtration function through their
interdigitated foot processes. However, the mechanisms that govern the podocyte …
interdigitated foot processes. However, the mechanisms that govern the podocyte …