Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies,
including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and …

Podocytes exhibit a unique cytoskeletal architecture that is fundamentally linked to their
function in maintaining the kidney filtration barrier. The cytoskeleton regulates podocyte …

Podocyte injury has a pivotal role in the pathogenesis of diabetic nephropathy (DN).
MicroRNA-27a (miR-27a), peroxisome proliferator-activated receptor γ (PPARγ) and β …

Fluorescence microscopy, in particular immunofluorescence microscopy, has been used
extensively for the assessment of kidney function and pathology for both research and …

Podocyte and glomerular research is center stage for the development of improved
preventive and therapeutic strategies for chronic progressive kidney diseases. Held April 3 …

Catalpol, an iridoid glycoside extracted from Rehmannia glutinosa, has been found to
ameliorate diabetic nephropathy (DN), but the mechanism has not been clarified. Podocyte …

Background Synaptopodin (Synpo) is an actin-associated protein in podocytes and dendritic
spines. Many functions in regulating the actin cytoskeleton via RhoA and other pathways …

Proteinuric kidney diseases are a group of disorders with diverse pathological mechanisms
associated with significant losses of protein in the urine. The glomerular filtration barrier …

Increased glomerular capillary pressure (glomerular hypertension) and increased
glomerular filtration rate (glomerular hyperfiltration) have been proven to cause …

Podocytes play a pivotal role in maintaining glomerular filtration function through their
interdigitated foot processes. However, the mechanisms that govern the podocyte …