EGFR-targeted therapies in the post-genomic era

MJ Xu, DE Johnson, JR Grandis - Cancer and Metastasis Reviews, 2017 - Springer
Over 90% of head and neck cancers overexpress the epidermal growth factor receptor
(EGFR). In diverse tumor types, EGFR overexpression has been associated with poorer …

Revenge of the “sit”: how lifestyle impacts neuronal and cognitive health through molecular systems that interface energy metabolism with neuronal plasticity

S Vaynman, F Gomez‐Pinilla - Journal of neuroscience …, 2006 - Wiley Online Library
Exercise, a behavior that is inherently associated with energy metabolism, impacts the
molecular systems important for synaptic plasticity and learning and memory. This implies …

Response to ERBB3-Directed Targeted Therapy in NRG1-Rearranged Cancers

A Drilon, R Somwar, BP Mangatt, H Edgren… - Cancer discovery, 2018 - AACR
NRG1 rearrangements are oncogenic drivers that are enriched in invasive mucinous
adenocarcinomas (IMA) of the lung. The oncoprotein binds ERBB3–ERBB2 heterodimers …

Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive function

Q Ding, S Vaynman, M Akhavan, Z Ying… - Neuroscience, 2006 - Elsevier
The ability of exercise to benefit neuronal and cognitive plasticity is well recognized. This
study reveals that the effects of exercise on brain neuronal and cognitive plasticity are in part …

Brain‐derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition

F Gomez‐Pinilla, S Vaynman… - European Journal of …, 2008 - Wiley Online Library
Brain‐derived neurotrophic factor (BDNF) has been shown to mediate the effects of exercise
on synaptic plasticity and cognitive function, in a process in which energy metabolism …

[HTML][HTML] The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase (p110α) pathway

JR McMullen, T Shioi, WY Huang, L Zhang… - Journal of Biological …, 2004 - ASBMB
Insulin-like growth factor 1 (IGF1) was considered a potential candidate for the treatment of
heart failure. However, some animal studies and clinical trials have questioned whether …

Contact-dependent inhibition of EGFR signaling by Nf2/Merlin

M Curto, BK Cole, D Lallemand, CH Liu… - The Journal of cell …, 2007 - rupress.org
The neurofibromatosis type 2 (NF2) tumor suppressor, Merlin, is a membrane/cytoskeleton-
associated protein that mediates contact-dependent inhibition of proliferation. Here we show …

Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases?

TJ Smith - Pharmacological reviews, 2010 - ASPET
This topically limited review explores the relationship between the immune system and
insulin-like growth factors (IGF-I and IGF-II) and the proteins through which they act …

Wound healing and expression of antimicrobial peptides/polypeptides in human keratinocytes, a consequence of common growth factors

OE Sørensen, JB Cowland… - The Journal of …, 2003 - journals.aai.org
In addition to acting as a physical barrier against microorganisms, the skin produces
antimicrobial peptides and proteins. After wounding, growth factors are produced to …

Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors

BC Paria, W Ma, J Tan, S Raja… - Proceedings of the …, 2001 - National Acad Sciences
The implantation of a blastocyst into a receptive uterus is associated with a series of events,
namely the attachment reaction followed by decidualization of the stroma. Previous studies …