Abstract Beta-2-Glycoprotein I (β2GPI) plays a number of essential roles throughout the
body. β2GPI, C-reactive protein and thrombomodulin are the only three proteins that …

Diagnosis of antiphospholipid syndrome (APS) requires the presence of a clinical criterion
(thrombosis and/or pregnancy morbidity), combined with persistently circulating …

Background Critically ill patients with coronavirus disease 2019 (COVID-19) have a
profound hypercoagulable state and often develop coagulopathy which leads to organ …

Autoimmune rheumatic diseases are characterised by an abnormal immune system
response, complement activation, cytokines dysregulation and inflammation. In last years …

Antiphospholipid syndrome, also known as 'Hughes Syndrome', is an autoimmune disease
characterised by a set of clinical manifestations, almost all of which are direct or indirect …

Recurrent thrombosis and miscarriages are the main clinical manifestations of
antiphospholipid syndrome (APS). Although most patients display both clinical signs, some …

Antiphospholipid antibodies (aPL) are mandatory for the diagnosis but are also a risk factor
for the antiphospholipid syndrome (APS) clinical manifestations. Lupus anticoagulant (LA) …

Objective Miscarriage affects 1 in 7 pregnancies, and antiphospholipid autoantibodies
(aPLs) are one of the biggest risk factors for recurrent pregnancy loss. While aPLs target the …

Anti-phospholipid syndrome (APS) is an acquired pro-thrombotic autoimmune disease that
predisposes to thrombotic events and/or obstetric complications, in the persistent presence …

Antibodies against β2 glycoprotein I (anti-β2GPI) have been identified as the main
pathogenic autoantibody subset in anti-phospholipid syndrome (APS); the most relevant …