The tumor suppressor and transcription factor p53 plays critical roles in tumor prevention by
orchestrating a wide variety of cellular responses, including damaged cell apoptosis …

Cancer stem cells (CSCs), known also as tumor-initiating cells, are quiescent, pluripotent,
self-renewing neoplastic cells that were first identified in hematologic tumors and soon after …

Simple Summary This review describes in a very detailed and exhaustive approach the
literature of these last 20 years on glioblastoma targeted therapies in Phases II-IV of 257 …

Glioblastoma multiforme (GBM) is among the most incurable cancers. GBMs survival rate
has not markedly improved, despite new radical surgery protocols, the introduction of new …

Since its first description, Western blot has been widely used in molecular labs. It constitutes
a multistep method that allows the detection and/or quantification of proteins from simple to …

Over the years, researchers in drug discovery have taken advantage of the use of privileged
structures to design innovative hit/lead molecules. The α-ketoamide motif is found in many …

A novel optical label-free bio-sensing platform based on a new class of resonances
supported in a photonic crystal metasurface is reported herein. Molecular binding is …

Simple Summary The translocator protein (TSPO) has been under extensive investigation as
a specific marker in positron emission tomography (PET) to visualize brain lesions following …

MDM2 and MDM4 are key negative regulators of p53, an important protein involved in
several cell processes (eg cell cycle and apoptosis). Not surprisingly, the p53 tumor …

Translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor
(PBR), is an outer mitochondrial membrane protein. TSPO has been shown to cooperate …