The hasubanan and acutumine alkaloids comprise a large collection of aza-propellane
natural products that possess varying degrees of structural complexity and biological activity …

Herein, we report a concise and divergent synthesis of the complex hasubanan alkaloids
metaphanine and oxoepistephamiersine from commercially available and inexpensive …

Comment: The quaternary stereogenic center within ketone F is set by an enantioselective
conjugate addition into nitroethene, mediated by Takemotos catalyst (D). Semireduction with …