Somatic or acquired mutations are postzygotic genetic variations that can occur within any
tissue. These mutations accumulate during aging and have classically been linked to …

Clonal hematopoiesis (CH), the clonal expansion of a blood stem cell and its progeny driven
by somatic driver mutations, affects over a third of people, yet remains poorly understood …

Clonal hematopoiesis of indeterminate potential (CHIP) refers to the expansion of cells of
hematopoietic lineage that carry acquired somatic alterations associated with hematologic …

Background Clonal hematopoiesis of indeterminate potential (CHIP) is an inflammatory
premalignant disorder resulting from acquired genetic mutations in hematopoietic stem cells …

Canakinumab, a monoclonal antibody targeting proinflammatory cytokine interleukin-1β (IL-
1β), improved hemoglobin levels while preventing recurrent cardiovascular events in the …

Abstract Purpose of Review Telomere biology disorders (TBDs) are cancer-predisposing
multisystemic diseases that portend a higher risk of transforming into myeloid neoplasms …

LGL disorders are rare hematological neoplasias with remarkable phenotypic, genotypic
and clinical heterogeneity. Despite these constraints, many achievements have been …

T cell large granular lymphocyte leukemia (T-LGLL) is an interesting case at the intersection
of autoimmunity and cancer. In T-LGLL, T cells with somatic pathogenic mutations (mainly in …

Clonal hematopoiesis (CH) is characterized by somatic mutations in blood cells of
individuals without hematologic disease. While the mutational landscape of CH in peripheral …

With advances in sequencing, individuals with clonal hematopoiesis of indeterminate
potential (CHIP) are increasingly being identified, making it essential to understand its …