Longer human lives have led to a global burden of late-life disease. However, some older
people experience little ill health, a trait that should be extended to the general population …

Exercise intolerance (EI) is the primary manifestation of chronic heart failure with preserved
ejection fraction (HFpEF), the most common form of heart failure among older individuals …

Caloric restriction (CR) without malnutrition extends lifespan and delays the onset of age-
related disorders in most species but its impact in nonhuman primates has been …

Calorie restriction (CR), a nutritional intervention of reduced energy intake but with adequate
nutrition, has been shown to extend healthspan and lifespan in rodent and primate models …

Summary Exercise training ('exercise') and hypocaloric diet ('diet') are frequently prescribed
for weight loss in obesity. Whilst body weight changes are commonly used to evaluate …

Background: The carbohydrate–insulin model of obesity posits that habitual consumption of
a high-carbohydrate diet sequesters fat within adipose tissue because of hyperinsulinemia …

Calorie restriction (CR), the reduction of dietary intake below energy requirements while
maintaining optimal nutrition, is the only known nutritional intervention with the potential to …

Physical activity and exercise are key components of energy expenditure and therefore of
energy balance. Changes in energy balance alter fat mass. It is therefore reasonable to ask …

Western lifestyles differ markedly from those of our hunter-gatherer ancestors, and these
differences in diet and activity level are often implicated in the global obesity pandemic …

Increased life expectancy combined with the aging baby boomer generation has resulted in
an unprecedented global expansion of the elderly population. The growing population of …