The global burden of antimicrobial resistance–urinary tract infections
S Von Vietinghoff, O Shevchuk… - Nephrology Dialysis …, 2024 - academic.oup.com
Antimicrobial resistance (AMR) has emerged as a significant global healthcare problem.
Antibiotic use has accelerated the physiologic process of AMR, particularly in Gram-negative …
Antibiotic use has accelerated the physiologic process of AMR, particularly in Gram-negative …
Evolutionary trajectories toward high-level β-lactam/β-Lactamase inhibitor resistance in the presence of multiple β-lactamases
F Rajer, L Allander, PA Karlsson… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
ABSTRACT β-Lactam antibiotics are the first choice for the treatment of most bacterial
infections. However, the increased prevalence of β-lactamases, in particular extended …
infections. However, the increased prevalence of β-lactamases, in particular extended …
Antibiotic resistance begets more resistance: chromosomal resistance mutations mitigate fitness costs conferred by multi-resistant clinical plasmids
RR Nair, DI Andersson, OM Warsi - Microbiology Spectrum, 2024 - Am Soc Microbiol
Plasmids are the primary vectors of horizontal transfer of antibiotic resistance genes among
bacteria. Previous studies have shown that the spread and maintenance of plasmids among …
bacteria. Previous studies have shown that the spread and maintenance of plasmids among …
Interaction with a phage gene underlie costs of a β-lactamase
HY Lai, TF Cooper - MBio, 2024 - Am Soc Microbiol
The fitness cost of an antibiotic resistance gene (ARG) can differ across host strains, creating
refuges that allow the maintenance of an ARG in the absence of direct selection for its …
refuges that allow the maintenance of an ARG in the absence of direct selection for its …
Impact of antimicrobial use on abundance of antimicrobial resistance genes in chicken flocks in Vietnam
Abstract Objectives We investigated longitudinally Vietnamese small-scale chicken flocks in
order to characterize changes in antimicrobial resistance gene (ARG) content over their life …
order to characterize changes in antimicrobial resistance gene (ARG) content over their life …
Quorum-sensing regulation of phenazine production heightens Pseudomonas aeruginosa resistance to ciprofloxacin
L Xia, Y Li, Y Wang, H Zhou, AA Dandekar… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
Quorum sensing is a type of cell–cell communication that modulates various biological
activities of bacteria. Previous studies indicate that quorum sensing contributes to the …
activities of bacteria. Previous studies indicate that quorum sensing contributes to the …
The fitness effects of codon composition of the horizontally transferred antibiotic resistance genes intensify at sub-lethal antibiotic levels
M Shaferman, M Gencel, N Alon… - Molecular Biology …, 2023 - academic.oup.com
The rampant variability in codon bias existing between bacterial genomes is expected to
interfere with horizontal gene transfer (HGT), a phenomenon that drives bacterial adaptation …
interfere with horizontal gene transfer (HGT), a phenomenon that drives bacterial adaptation …
Off-target integron activity leads to rapid plasmid compensatory evolution in response to antibiotic selection pressure
Integrons are mobile genetic elements that have played an important role in the
dissemination of antibiotic resistance. Under stress, the integron can generate combinatorial …
dissemination of antibiotic resistance. Under stress, the integron can generate combinatorial …
[HTML][HTML] Comparing the transmission of carbapenemase-producing and extended-spectrum beta-lactamase-producing Escherichia coli between broiler chickens
N Dankittipong, JB Alderliesten… - Preventive Veterinary …, 2023 - Elsevier
The emergence of carbapenemase-producing Enterobacteriaceae (CPE) is a threat to
public health, because of their resistance to clinically important carbapenem antibiotics. The …
public health, because of their resistance to clinically important carbapenem antibiotics. The …
[PDF][PDF] JAC-Antimicrobial Resistance
Objective: To determine the impact of the COVID-19 pandemic on antimicrobial consumption
and trends of therapeutic drugs for COVID-19 treatments, including corticosteroids …
and trends of therapeutic drugs for COVID-19 treatments, including corticosteroids …