Chitosan is the polymer of choice for delivery of the active moieties to the colon due to its
cationic nature that enables strong mucosal attachment. Chitosan is explored for …

Highlights•pH is vital for the normal functioning of the body.•Drug targeting has been widely
used to increase efficacy and reduce adverse effects.•pH variation in different tissues and …

Biological macromolecules evolved to perform their function in specific cellular environment
(subcellular compartments or tissues); therefore, they should be adapted to the biophysical …

Site-specific colon drug delivery is a practical approach for the treatment of local diseases of
the colon with several advantages such as rapid onset of action and reduction of the dosage …

Introduction Recent statistics have reported colorectal cancer (CRC) as the second leading
cause of cancer-associated deaths in the world. Early diagnosis of CRC may help to reduce …

Oral colon-targeted drug delivery systems have gained enormous attention among
researchers in the last two decades. The significance of this site-specific drug delivery …

The study aimed to fabricate and evaluate Meloxicam (MLX) loaded Hydroxypropyl
Methylcellulose (HPMC) microparticles for colon targeting because MLX is a potent …

The objective of the present study was to develop a colon targeted system of meloxicam for
potential application in the prophylaxis of colorectal cancer. Efficacy of selective …

Day by day there are new developments in field of colon specific drug delivery system.
Colonic drug delivery has gained increased importance not just for the delivery of the drugs …

The major challenge involved in the treatment of inflammatory bowel disease is targeted
delivery of the drug at the site of inflammation. As nanoparticles possess the ability to …