Signaling pathways that mediate the normal functions of growth factors are commonly
subverted in cancer. Oncogenes identified by a variety of approaches have been shown to …

Insulin-like growth factor-I (IGF-I) and its cognate receptor, the type 1 IGF receptor (IGF1R),
as well as high-affinity IGF binding proteins (IGFBP) that modulate IGF-I actions, are …

In cultures of embryonic and adult mouse striatum, we previously demonstrated that EGF
induces the proliferation of putative stem cells, which give rise to spheres of undifferentiated …

PDCF promotes the growth of oligodendrocyte type-2 astrocyte (O-2A) glial progenitor cells
and allows their timely differentiation into oligodendrocytes, the CNS myelin-forming cells …

Primary embryonic hippocampal neurons can develop morphologically and functionally in
culture but do not survive more than a few weeks. It has been reported that basic fibroblast …

We have established a permanent cell line (CG‐4) of rat central nervous system glial
precursors from primary cultures of bipotential oligodendrocyte‐type 2‐astrocyte (O‐2A) …

In the central nervous system, myelination of axons occurs when oligodendrocyte
progenitors undergo terminal differentiation and initiate process formation and axonal …

Local injections of lysolecithin are commonly used to produce areas of demyelination in the
CNS. For the mouse, the demyelinating initial phase of lesion development has been …

Oligodendrocyte-type-2 astrocyte (O-2A) glial progenitor cells undergo a limited number of
mitotic divisions in response to PDGF before differentiating into oligodendrocytes, the myelin …

During central nervous system (CNS) development, glial precursors proliferate in
subventricular zones and then migrate throughout the CNS to adopt their final destinations …