Parkinson disease (PD) is an age-related neurodegenerative disorder that affects as many
as 1–2% of persons aged 60 years and older. With the aging of the population, the …

The potential to generate virtually any differentiated cell type from embryonic stem cells
(ESCs) offers the possibility to establish new models of mammalian development and to …

To model human neural-cell-fate specification and to provide cells for regenerative
therapies, we have developed a method to generate human neural progenitors and neurons …

Stem cell–based approaches have received much hype as potential treatments for
neurodegenerative disorders. Indeed, transplantation of stem cells or their derivatives in …

Neonatal hypoxic ischemic encephalopathy (HIE) is a devastating disease that primarily
causes neuronal and white matter injury and is among the leading cause of death among …

Neurologic impairments are usually irreversible as a result of limited regeneration in the
central nervous system. Therefore, based on the regenerative capacity of stem cells …

By sequentially applying sonic hedgehog (C25II) and CHIR99021 (GSK3β inhibitor) to
induce the midbrain floor plate (FP) progenitors and fibroblast growth factor 8 (FGF8) to …

In Parkinson's disease (PD), the main pathology is a loss of nigrostriatal dopamine (DA)
neurons. Clinical trials with intrastriatal transplantation of human embryonic mesencephalic …

Recent progress in the field of the stem cell research has given new hopes to treat and even
cure diverse degenerative disorders and incurable diseases in human. Particularly, the …

Cellular therapy with adult stem cells appears as an opportunity for treatment of Parkinson's
disease. To validate this approach, we studied the effects of transplantation of rat adult bone …