Vaccinia virus-mediated cancer immunotherapy: cancer vaccines and oncolytics
Cancer vaccines and oncolytic immunotherapy are promising treatment strategies with
potential to provide greater clinical benefit to patients with advanced-stage cancer. In …
potential to provide greater clinical benefit to patients with advanced-stage cancer. In …
Cancer immunotherapy: broadening the scope of targetable tumours
J van den Bulk, EME Verdegaal… - Open …, 2018 - royalsocietypublishing.org
Cancer immunotherapy has experienced remarkable advances in recent years. Striking
clinical responses have been achieved for several types of solid cancers (eg melanoma …
clinical responses have been achieved for several types of solid cancers (eg melanoma …
Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer
PW Kantoff, TJ Schuetz, BA Blumenstein… - Journal of Clinical …, 2010 - ascopubs.org
Purpose Therapeutic prostate-specific antigen (PSA)–targeted poxviral vaccines for prostate
cancer have been well tolerated. PROSTVAC-VF treatment was evaluated for safety and for …
cancer have been well tolerated. PROSTVAC-VF treatment was evaluated for safety and for …
Irradiation of tumor cells up-regulates Fas and enhances CTL lytic activity and CTL adoptive immunotherapy
M Chakraborty, SI Abrams, K Camphausen… - The Journal of …, 2003 - journals.aai.org
CD8+ CTL play important roles against malignancy in both active and passive
immunotherapy. Nonetheless, the success of antitumor CTL responses may be improved by …
immunotherapy. Nonetheless, the success of antitumor CTL responses may be improved by …
The evolution of poxvirus vaccines
After Edward Jenner established human vaccination over 200 years ago, attenuated
poxviruses became key players to contain the deadliest virus of its own family: Variola virus …
poxviruses became key players to contain the deadliest virus of its own family: Variola virus …
Prostate cancer as a model for tumour immunotherapy
CG Drake - Nature Reviews Immunology, 2010 - nature.com
Advances in basic immunology have led to an improved understanding of the interactions
between the immune system and tumours, generating renewed interest in approaches that …
between the immune system and tumours, generating renewed interest in approaches that …
Targeted and armed oncolytic poxviruses: a novel multi-mechanistic therapeutic class for cancer
DH Kirn, SH Thorne - Nature Reviews Cancer, 2009 - nature.com
Viruses have been engineered for cancer therapy in a variety of ways. Approaches include
non-replicating gene therapy vectors, cancer vaccines and oncolytic viruses, but the clinical …
non-replicating gene therapy vectors, cancer vaccines and oncolytic viruses, but the clinical …
Therapeutic cancer vaccines: current status and moving forward
J Schlom - Journal of the National Cancer Institute, 2012 - academic.oup.com
Concurrent with US Food and Drug Administration (FDA) approval of the first therapeutic
cancer vaccine, a wide spectrum of other cancer vaccine platforms that target a diverse …
cancer vaccine, a wide spectrum of other cancer vaccine platforms that target a diverse …
External beam radiation of tumors alters phenotype of tumor cells to render them susceptible to vaccine-mediated T-cell killing
M Chakraborty, SI Abrams, CN Coleman… - Cancer research, 2004 - AACR
Local radiation is an established therapy for human tumors. Radiation also has been shown
to alter the phenotype of target tissue, including gene products that may make tumor cells …
to alter the phenotype of target tissue, including gene products that may make tumor cells …
White paper on microbial anti-cancer therapy and prevention
Abstract In this White Paper, we discuss the current state of microbial cancer therapy. This
paper resulted from a meeting ('Microbial Based Cancer Therapy') at the US National …
paper resulted from a meeting ('Microbial Based Cancer Therapy') at the US National …