Portal hypertension, defined as increased pressure in the portal vein, develops as a
consequence of increased intrahepatic vascular resistance due to the dysregulation of liver …

Portal hypertension is a major complication of cirrhosis, and its consequences, including
ascites, esophageal varices, hepatic encephalopathy, and hepatorenal syndrome, lead to …

Background: Primary liver cancer, around 90% are hepatocellular carcinoma in China, is the
fourth most common malignancy and the second leading cause of tumor-related death …

Background Clinical decompensation of cirrhosis is associated with poor prognosis.
Clinically significant portal hypertension (CSPH), defined by a hepatic venous pressure …

The prevention and management of bleeding and thrombosis in patients with cirrhosis
poses several difficult clinical questions. These Clinical Practice Guidelines have been …

Progression of nonalcoholic steatohepatitis (NASH) is incompletely characterized. We
analyzed data on longitudinal changes in liver histology, hepatic venous pressure gradient …

Increased vascular permeability facilitates metastasis. Emerging evidence indicates that
secreted microRNAs (miRNAs) may mediate the crosstalk between cancer and stromal cells …

METHODS: This is an international cohort study including patients with paired LSM/hepatic
venous pressure gradient (HVPG), LSM≥ 10 kPa, and no previous decompensation. Portal …

Background & Aims Lysyl oxidase-like 2 contributes to fibrogenesis by catalyzing cross-
linkage of collagen. We evaluated the safety and efficacy of simtuzumab, a monoclonal …

In patients with compensated advanced chronic liver disease (cACLD), the presence of
clinically significant portal hypertension (CSPH) and varices needing treatment (VNT) bears …