The advent of cancer therapeutics brought a paradigm shift from conventional therapy to
precision medicine. The new therapeutic modalities accomplished through the properties of …

The field of mechanically interlocked molecules (MIMs) has advanced rapidly in recent
years, with much work focused on their use in materials, sensing, and catalysis. However …

Tumor suppressor p53 can transcriptionally activate downstream genes in response to
stress, and then regulate the cell cycle, DNA repair, metabolism, angiogenesis, apoptosis …

A technique combining ion mobility spectrometry‐mass spectrometry (IMS‐MS) and
supercharging electrospray ionization (ESI) has been demonstrated to differentiate protein …

Bioconjugation is a powerful protein modification strategy to improve protein properties.
Herein, we report mechano-bioconjugation as a novel approach to empower fusion protein …

Natural proteins exhibit rich structural diversity based on the folds of an invariably linear
chain. Macromolecular catenanes that cooperatively fold into a single domain do not belong …

Unlike small molecules, the topological complexity of macromolecules remains largely
unexplored due to the huge synthetic challenge. Herein, we report the development of …

The coupling of chromatography with mass spectrometry (MS) has becoming a routine
technique in proteomics for protein primary sequence and post translational modification …

Abstract Information-rich molecules provide opportunities for evolution. Genetically
engineered materials are superior in that their properties are coded within genetic …

Topology has been recognized as a unique dimension in molecular engineering, yet the
topological diversity remains largely untapped, especially in macromolecules. Herein, we …