Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
synaptic dysfunction and accumulation of abnormal aggregates formed by amyloid‐β …

Curcumin derived from turmeric is well documented for its anti-carcinogenic, antioxidant and
anti-inflammatory properties. Recent studies show that curcumin also possesses …

Protein kinase R (PKR) is an immune response protein that becomes activated by double-
stranded RNAs (dsRNAs). PKR overactivation is associated with degenerative diseases with …

Protein kinase RNA-activated (PKR) induces immune response by sensing viral double-
stranded RNAs (dsRNAs). However, growing evidence suggests that PKR can also be …

Dendritic mislocalization of microtubule associated protein tau is a hallmark of tauopathies,
but the role of dendritic tau is unknown. We now report that tau interacts with the RNA …

Chronic low-grade inflammation is a common hallmark of the aging process and many age-
related diseases. There is substantial evidence that persistent inflammation is associated …

Endoplasmic reticulum (ER) stress and its adaptive mechanism, the unfolded protein
response (UPR), are triggered by the accumulation of unfolded and misfolded proteins …

The amount and availability of proteins are regulated by their synthesis, degradation, and
transport. These processes can specifically, locally, and temporally regulate a protein or a …

Neuronal death and inflammatory response are two common pathological hallmarks of
acute central nervous system injury and chronic degenerative disorders, both of which are …

Mass spectrometry-based proteomics has considerably extended our knowledge about the
occurrence and dynamics of protein post-translational modifications (PTMs). So far …