Dysregulated cell division, which leads to aberrant cell proliferation, is one of the key
hallmarks of cancer. Therefore, therapeutic targets that block cell division would be effective …

Traditional Chinese medicine (TCM) has a long history of viewing an individual or patient as
a system with different statuses, and has accumulated numerous herbal formulae. The …

Indirubin plays an important role in the treatment of many chronic diseases and exhibits
strong anti-inflammatory activity. However, the molecular mode of action during mastitis …

Cyclin dependent kinases (CDKs) are serine/threonine kinases that are proposed as
promising candidate targets for cancer treatment. These proteins complexed with cyclins …

Covering: up to July 2020 Drugs derived from traditional Chinese medicine (TCM) include
both single chemical entities and multi-component preparations. Drugs of both types play a …

Cyclin-dependent kinases (CDK/Cyclins) form a family of heterodimeric kinases that play
central roles in regulation of cell cycle progression, transcription and other major biological …

Signal transducer and activator of transcription 3 (STAT3) is a latent cytoplasmic
transcription factor, originally discovered as a transducer of signal from cell surface …

The cell cycle is controlled by numerous mechanisms ensuring correct cell division. This
review will focus on these mechanisms, ie regulation of cyclin‐dependent kinases (CDK) by …

Current research in drug discovery from medicinal plants involves a multifaceted approach
combining botanical, phytochemical, biological, and molecular techniques. Medicinal plant …

Protein phosphorylation regulates most aspects of cell life, whereas abnormal
phosphorylation is a cause or consequence of disease. A growing interest in developing …