Synthesis of esters by immobilized-lipase-catalyzed condensation reaction of sugars and fatty acids in water-miscible organic solvent

S Adachi, T Kobayashi - Journal of bioscience and bioengineering, 2005 - Elsevier
A lipase-catalyzed condensation reaction in an organic solvent is a promising means of
synthesizing esters. Reaction equilibrium constant, which is usually defined on the basis of …

Kinetic Resolution of Profens by Enantioselective Esterification Catalyzed by Candida antarctica and Candida rugosa Lipases

A Sikora, T Siódmiak, MP Marszałł - Chirality, 2014 - Wiley Online Library
ABSTRACT Profens (2‐arylpropionic acids) are known as one of the major nonsteroidal
antiinflammatory drugs (NSAIDs) used in the treatment of inflammation associated with …

Preparation and characterization of immobilized lipase from Pseudomonas cepacia onto magnetic cellulose nanocrystals

SL Cao, YM Huang, XH Li, P Xu, H Wu, N Li, WY Lou… - Scientific reports, 2016 - nature.com
Magnetic cellulose nanocrystals (MCNCs) were prepared and used as an enzyme support
for immobilization of Pseudomonas cepacialipase (PCL). PCL was successfully immobilized …

Towards sustainable kinetic resolution, a combination of bio-catalysis, flow chemistry and bio-based solvents

A Iemhoff, J Sherwood, CR McElroy, AJ Hunt - Green Chemistry, 2018 - pubs.rsc.org
The esterification of 2-phenylpropionic acid was investigated as a model system for enzyme
catalysed (CALB, Novozyme 435) reactions in bio-based solvents. A multi-parameter …

Enantioselective esterification of ibuprofen with ethanol as reactant and solvent catalyzed by immobilized lipase: experimental and molecular modeling aspects

ML Foresti, M Galle, ML Ferreira… - Journal of Chemical …, 2009 - Wiley Online Library
BACKGROUND: In recent years enantioselective esterification of racemic ibuprofen
performed in organic co‐solvent media such as isooctane and cyclohexane and catalyzed …

Performance of free Candida antarctica lipase B in the enantioselective esterification of (R)-ketoprofen

AL Ong, AH Kamaruddin, S Bhatia, WS Long… - Enzyme and microbial …, 2006 - Elsevier
The performance of free Candida antarctica lipase B (CALB) in a mixed solvent system for
enantioselective esterification of (R)-ketoprofen, leaving the target product (S)-ketoprofen in …

Current technologies for the production of (S)-ketoprofen: Process perspective

AL Ong, AH Kamaruddin, S Bhatia - Process Biochemistry, 2005 - Elsevier
Ketoprofen (2-(3-benzoylphenyl)-propionic acid), belongs to the family of 2-arylpropionic
acids (profens), is one of the nonstreroidal anti-inflammatory drugs. The production of single …

Towards a green enantiomeric esterification of R/S-ketoprofen: A theoretical and experimental investigation

MV Toledo, C José, SE Collins, ML Ferreira… - Journal of Molecular …, 2015 - Elsevier
Abstract Methanol, ethanol, 1-and 2-propanol were used as reactants and solvents in the
esterification of R/S-ketoprofen catalyzed with Novozym® 435. The interaction of the …

Enantioseparation of (R,S)‐ketoprofen using Candida antarctica lipase B in an enzymatic membrane reactor

AL Ong, AH Kamaruddin, S Bhatia… - Journal of separation …, 2008 - Wiley Online Library
An enzymatic membrane reactor (EMR) for enantioseparation of (R, S)‐ketoprofen via
Candida antarctica lipase B (CALB) as biocatalyst was investigated. A comparative study of …

Enzymatic production of enantiopure ketoprofen in a solvent-free two-phase system

JN Jin, SH Lee, SB Lee - Journal of Molecular Catalysis B: Enzymatic, 2003 - Elsevier
Enzymatic hydrolysis conducted in a medium composed of solely substrate is considered to
resolve racemic ketoprofen esters. In a system composed of two components, the pure liquid …