Mathematical models of developmental vascular remodelling: A review
Over the past 40 years, there has been a strong focus on the development of mathematical
models of angiogenesis, while developmental remodelling has received little such attention …
models of angiogenesis, while developmental remodelling has received little such attention …
Endothelial cell apoptosis in angiogenesis and vessel regression
Blood vessel regression is an essential process for ensuring blood vessel networks function
at optimal efficiency and for matching blood supply to the metabolic needs of tissues as they …
at optimal efficiency and for matching blood supply to the metabolic needs of tissues as they …
Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification
Establishment of a functional vascular network is rate-limiting in embryonic development,
tissue repair and engineering. During blood vessel formation, newly generated endothelial …
tissue repair and engineering. During blood vessel formation, newly generated endothelial …
Dynamic endothelial cell rearrangements drive developmental vessel regression
Patterning of functional blood vessel networks is achieved by pruning of superfluous
connections. The cellular and molecular principles of vessel regression are poorly …
connections. The cellular and molecular principles of vessel regression are poorly …
YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development
Formation of blood vessel networks by sprouting angiogenesis is critical for tissue growth,
homeostasis and regeneration. How endothelial cells arise in adequate numbers and …
homeostasis and regeneration. How endothelial cells arise in adequate numbers and …
PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia
Activin receptor-like kinase 1 (ALK1) is an endothelial serine–threonine kinase receptor for
bone morphogenetic proteins (BMPs) 9 and 10. Inactivating mutations in the ALK1 gene …
bone morphogenetic proteins (BMPs) 9 and 10. Inactivating mutations in the ALK1 gene …
Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia
N Baeyens, B Larrivée, R Ola… - Journal of Cell …, 2016 - rupress.org
Morphogenesis of the vascular system is strongly modulated by mechanical forces from
blood flow. Hereditary hemorrhagic telangiectasia (HHT) is an inherited autosomal …
blood flow. Hereditary hemorrhagic telangiectasia (HHT) is an inherited autosomal …
Non-canonical Wnt signalling modulates the endothelial shear stress flow sensor in vascular remodelling
Endothelial cells respond to molecular and physical forces in development and vascular
homeostasis. Deregulation of endothelial responses to flow-induced shear is believed to …
homeostasis. Deregulation of endothelial responses to flow-induced shear is believed to …
SMAD4 prevents flow induced arteriovenous malformations by inhibiting casein kinase 2
Background: Hereditary hemorrhagic telangiectasia (HHT) is an inherited vascular disorder
that causes arteriovenous malformations (AVMs). Mutations in the genes encoding Endoglin …
that causes arteriovenous malformations (AVMs). Mutations in the genes encoding Endoglin …
DACH1 stimulates shear stress-guided endothelial cell migration and coronary artery growth through the CXCL12–CXCR4 signaling axis
Sufficient blood flow to tissues relies on arterial blood vessels, but the mechanisms
regulating their development are poorly understood. Many arteries, including coronary …
regulating their development are poorly understood. Many arteries, including coronary …