Mathematical models of developmental vascular remodelling: A review

JR Crawshaw, JA Flegg, MO Bernabeu… - PLoS Computational …, 2023 - journals.plos.org
Over the past 40 years, there has been a strong focus on the development of mathematical
models of angiogenesis, while developmental remodelling has received little such attention …

Endothelial cell apoptosis in angiogenesis and vessel regression

EC Watson, ZL Grant, L Coultas - Cellular and Molecular Life Sciences, 2017 - Springer
Blood vessel regression is an essential process for ensuring blood vessel networks function
at optimal efficiency and for matching blood supply to the metabolic needs of tissues as they …

Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification

JS Fang, BG Coon, N Gillis, Z Chen, J Qiu… - Nature …, 2017 - nature.com
Establishment of a functional vascular network is rate-limiting in embryonic development,
tissue repair and engineering. During blood vessel formation, newly generated endothelial …

Dynamic endothelial cell rearrangements drive developmental vessel regression

CA Franco, ML Jones, MO Bernabeu, I Geudens… - PLoS …, 2015 - journals.plos.org
Patterning of functional blood vessel networks is achieved by pruning of superfluous
connections. The cellular and molecular principles of vessel regression are poorly …

YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development

F Neto, A Klaus-Bergmann, YT Ong, S Alt, AC Vion… - elife, 2018 - elifesciences.org
Formation of blood vessel networks by sprouting angiogenesis is critical for tissue growth,
homeostasis and regeneration. How endothelial cells arise in adequate numbers and …

PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia

R Ola, A Dubrac, J Han, F Zhang, JS Fang… - Nature …, 2016 - nature.com
Activin receptor-like kinase 1 (ALK1) is an endothelial serine–threonine kinase receptor for
bone morphogenetic proteins (BMPs) 9 and 10. Inactivating mutations in the ALK1 gene …

Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia

N Baeyens, B Larrivée, R Ola… - Journal of Cell …, 2016 - rupress.org
Morphogenesis of the vascular system is strongly modulated by mechanical forces from
blood flow. Hereditary hemorrhagic telangiectasia (HHT) is an inherited autosomal …

Non-canonical Wnt signalling modulates the endothelial shear stress flow sensor in vascular remodelling

CA Franco, ML Jones, MO Bernabeu, AC Vion… - Elife, 2016 - elifesciences.org
Endothelial cells respond to molecular and physical forces in development and vascular
homeostasis. Deregulation of endothelial responses to flow-induced shear is believed to …

SMAD4 prevents flow induced arteriovenous malformations by inhibiting casein kinase 2

R Ola, SH Künzel, F Zhang, G Genet, R Chakraborty… - Circulation, 2018 - Am Heart Assoc
Background: Hereditary hemorrhagic telangiectasia (HHT) is an inherited vascular disorder
that causes arteriovenous malformations (AVMs). Mutations in the genes encoding Endoglin …

DACH1 stimulates shear stress-guided endothelial cell migration and coronary artery growth through the CXCL12–CXCR4 signaling axis

AH Chang, BC Raftrey, G D'Amato… - Genes & …, 2017 - genesdev.cshlp.org
Sufficient blood flow to tissues relies on arterial blood vessels, but the mechanisms
regulating their development are poorly understood. Many arteries, including coronary …