Our laboratory uses a model of intrauterine growth restriction (IUGR) induced by placental
insufficiency in the rat to examine the developmental origins of adult disease. In this model …

Background Hypercortisolism as a sign of hypothamamus-pituitary-adrenocortical (HPA)
axis overactivity and sleep EEG changes are frequently observed in depression. Closely …

Background: Angiotensin peptides play roles in brain tumor infiltration and associated
angiogenesis. Materials and Methods: We explored the roles of soluble and membrane …

Hypertension is the major risk factor for coronary heart disease, stroke, and renal disease.
Also, it is probably the most important risk factor for peripheral vascular disease and …

Hypercholesterolemia and low testosterone concentrations in men are associated with a
high risk factor for atherosclerosis. It is known that cholesterol serves as the major precursor …

The mammalian target of rapamycin complex 1 (mTORC1) is known to be a central cellular
nutrient sensor and master regulator of protein metabolism; therefore, it is indispensable for …

Angiotensin peptides regulate vascular tone and natriohydric balance through the renin
angiotensin system (RAS) and are related with the angiogenesis which plays an important …

Objective: Pineal function has been considered particularly as a neuroendocrine modulator
in hormone responsive tumors, like the hormone-dependent mammary tumors. The …

Men are at greater risk of cardiovascular and renal diseases than women. Several
hypertensive rat models also exhibit gender differences in blood pressure. Although the …

Objective To delineate clinical presentation and outcome of Autosomal Dominant Polycystic
Kidney Disease (ADPKD) in terms of need for renal replacement therapy of kidney …