Reprogramming Müller glia to regenerate retinal neurons
M Lahne, M Nagashima, DR Hyde… - Annual Review of …, 2020 - annualreviews.org
In humans, various genetic defects or age-related diseases, such as diabetic retinopathies,
glaucoma, and macular degeneration, cause the death of retinal neurons and profound …
glaucoma, and macular degeneration, cause the death of retinal neurons and profound …
Contribution of Müller cells in the diabetic retinopathy development: Focus on oxidative stress and inflammation
R Carpi-Santos, RA de Melo Reis, FCA Gomes… - Antioxidants, 2022 - mdpi.com
Diabetic retinopathy is a neurovascular complication of diabetes and the main cause of
vision loss in adults. Glial cells have a key role in maintenance of central nervous system …
vision loss in adults. Glial cells have a key role in maintenance of central nervous system …
The Hippo pathway blocks mammalian retinal Müller glial cell reprogramming
EM Rueda, BM Hall, MC Hill, PG Swinton, X Tong… - Cell reports, 2019 - cell.com
In response to retinal damage, the Müller glial cells (MGs) of the zebrafish retina have the
ability to undergo a cellular reprogramming event in which they enter the cell cycle and …
ability to undergo a cellular reprogramming event in which they enter the cell cycle and …
Müller glia-mediated retinal regeneration
H Gao, X Huang, XI Chen, H Xu - Molecular neurobiology, 2021 - Springer
Müller glia originate from neuroepithelium and are the principal glial cells in the retina.
During retinal development, Müller glia are one of the last cell types to be born. In lower …
During retinal development, Müller glia are one of the last cell types to be born. In lower …
The chick eye in vision research: An excellent model for the study of ocular disease
CE Wisely, JA Sayed, H Tamez, C Zelinka… - Progress in retinal and …, 2017 - Elsevier
The domestic chicken, Gallus gallus, serves as an excellent model for the study of a wide
range of ocular diseases and conditions. The purpose of this manuscript is to outline some …
range of ocular diseases and conditions. The purpose of this manuscript is to outline some …
NF-κB signaling regulates the formation of proliferating Müller glia-derived progenitor cells in the avian retina
Retinal regeneration is robust in some cold-blooded vertebrates, but this process is
ineffective in warm-blooded vertebrates. Understanding the mechanisms that suppress the …
ineffective in warm-blooded vertebrates. Understanding the mechanisms that suppress the …
Inflammation‐induced mammalian target of rapamycin signaling is essential for retina regeneration
Z Zhang, H Hou, S Yu, C Zhou, X Zhang, N Li, S Zhang… - Glia, 2020 - Wiley Online Library
Upon retina injury, Müller glia in the zebrafish retina respond by generating multipotent
progenitors to repair the retina. However, the complete mechanisms underlying retina …
progenitors to repair the retina. However, the complete mechanisms underlying retina …
Midkine is neuroprotective and influences glial reactivity and the formation of Müller glia‐derived progenitor cells in chick and mouse retinas
Recent studies suggest midkine (MDK) is involved in the development and regeneration of
the zebrafish retina. We investigate the expression patterns of MDK and related factors, roles …
the zebrafish retina. We investigate the expression patterns of MDK and related factors, roles …
Cannabinoid signaling promotes the de‐differentiation and proliferation of Müller glia‐derived progenitor cells
WA Campbell, S Blum, A Reske, T Hoang… - Glia, 2021 - Wiley Online Library
Endocannabinoids (eCB) are lipid‐based neurotransmitters that are known to influence
synaptic function in the visual system. eCBs are also known to suppress neuroinflammation …
synaptic function in the visual system. eCBs are also known to suppress neuroinflammation …
Jak/Stat signaling regulates the proliferation and neurogenic potential of Müller glia-derived progenitor cells in the avian retina
Müller glia are capable of de-differentiating and proliferating to become Müller glia-derived
progenitor cells (MGPCs) with the ability to regenerate retinal neurons. One of the cell …
progenitor cells (MGPCs) with the ability to regenerate retinal neurons. One of the cell …