The T‐cell response is central in the adaptive immune‐mediated elimination of pathogen‐
infected and/or cancer cells. This activated T‐cell response can inflict an overwhelming …

Major advances in preventing, delaying, or curing individual pathologies are responsible for
an increasingly long life span in the developed parts of our planet, and indeed reaching …

Combination antiretroviral therapy for HIV infection improves immune function and
eliminates the risk of AIDS-related complications but does not restore full health. HIV …

A low CD4/CD8 ratio in elderly HIV-uninfected adults is associated with increased morbidity
and mortality. A subset of HIV-infected adults receiving effective antiretroviral therapy (ART) …

COVID-19 is a distinctive infection characterized by elevated inter-human transmission and
presenting from absence of symptoms to severe cytokine storm that can lead to dismal …

HIV infection induces phenotypic and functional changes to CD8+ T cells defined by the
coordinated upregulation of a series of negative checkpoint receptors that eventually result …

Stem cells are defined by the ability to self-renew and to generate differentiated progeny,
qualities that are maintained by evolutionarily conserved pathways that can lead to cancer …

Systemic chronic immune activation is considered today as the driving force of CD 4+ T‐cell
depletion and acquired immunodeficiency syndrome (AIDS). A residual chronic immune …

The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

Natural killer (NK) cells are lymphocytes of the innate immune system that, following
differentiation from CD56bright to CD56dim cells, have been thought to retain fixed …