Analysis pipeline for the epistasis search–statistical versus biological filtering

X Sun, Q Lu, S Mukherjee, PK Crane, R Elston… - Frontiers in …, 2014 - frontiersin.org
Gene–gene interactions may contribute to the genetic variation underlying complex traits but
have not always been taken fully into account. Statistical analyses that consider gene–gene …

Allele-specific network reveals combinatorial interaction that transcends small effects in psoriasis GWAS

S Climer, AR Templeton, W Zhang - PLoS computational biology, 2014 - journals.plos.org
Hundreds of genetic markers have shown associations with various complex diseases, yet
the “missing heritability” remains alarmingly elusive. Combinatorial interactions may account …

Human Leukocyte Antigen alleles as an aid to STR in complex forensic DNA samples

A Kuffel, A Gray, NN Daeid - Science & Justice, 2020 - Elsevier
Human biological samples with multiple contributors remain one of the most challenging
aspects of DNA typing within a forensic science context. With the increasing sensitivity of …

The interaction between PAX9 rs2073244 and passive smoking during pregnancy on low birth weight in newborns: a case–control study

Q Lou, S Wu, J Zhang, R Xie, X Wu… - International Journal of …, 2024 - Taylor & Francis
To explore whether rs2073244 at PAX9 increased susceptibility for full-term low birth weight
infants and whether indoors passive smoking exposure has a combined effect with …

[HTML][HTML] Combinations of genetic variants occurring exclusively in patients

E Mellerup, GL Møller - Computational and Structural Biotechnology …, 2017 - Elsevier
In studies of polygenic disorders, scanning the genetic variants can be used to identify
variant combinations. Combinations that are exclusively found in patients can be separated …

Combinations of genetic variants associated with bipolar disorder

E Mellerup, OA Andreassen, B Bennike, H Dam… - Plos one, 2017 - journals.plos.org
The main objective of the study was to find genetic variants that in combination are
significantly associated with bipolar disorder. In previous studies of bipolar disorder …

Alcohol intake and Alcohol–SNP interactions Associated with prostate Cancer aggressiveness

HY Lin, X Wang, TS Tseng, YH Kao, Z Fang… - Journal of clinical …, 2021 - mdpi.com
Excessive alcohol intake is a well-known modifiable risk factor for many cancers. It is still
unclear whether genetic variants or single nucleotide polymorphisms (SNPs) can modify …

New glutamatergic target for alcohol and substance use disorder medications

C Vadasz, M Saito - Psychopharmacology, 2014 - Springer
Traditionally, theories of dopamine reward (Wise 1996; Wise and Bozarth 1987) dominated
the field of alcohol and substance use disorder. The brain's most abundant neurotransmitter …

Test for association of common variants in GRM7 with alcohol consumption

WE Melroy-Greif, C Vadasz, HM Kamens… - Alcohol, 2016 - Elsevier
Recent work using a mouse model has identified the glutamate metabotropic receptor 7
(Grm7) gene as a strong candidate gene for alcohol consumption. Although there has been …

[PDF][PDF] Allele-Specific Network Reveals Combinatorial Interaction That Transcends Small Effects in Psoriasis

S Climer, AR Templeton, W Zhang - 2014 - academia.edu
Hundreds of genetic markers have shown associations with various complex diseases, yet
the ''missing heritability''remains alarmingly elusive. Combinatorial interactions may account …