Analysis pipeline for the epistasis search–statistical versus biological filtering
Gene–gene interactions may contribute to the genetic variation underlying complex traits but
have not always been taken fully into account. Statistical analyses that consider gene–gene …
have not always been taken fully into account. Statistical analyses that consider gene–gene …
Allele-specific network reveals combinatorial interaction that transcends small effects in psoriasis GWAS
Hundreds of genetic markers have shown associations with various complex diseases, yet
the “missing heritability” remains alarmingly elusive. Combinatorial interactions may account …
the “missing heritability” remains alarmingly elusive. Combinatorial interactions may account …
Human Leukocyte Antigen alleles as an aid to STR in complex forensic DNA samples
Human biological samples with multiple contributors remain one of the most challenging
aspects of DNA typing within a forensic science context. With the increasing sensitivity of …
aspects of DNA typing within a forensic science context. With the increasing sensitivity of …
The interaction between PAX9 rs2073244 and passive smoking during pregnancy on low birth weight in newborns: a case–control study
Q Lou, S Wu, J Zhang, R Xie, X Wu… - International Journal of …, 2024 - Taylor & Francis
To explore whether rs2073244 at PAX9 increased susceptibility for full-term low birth weight
infants and whether indoors passive smoking exposure has a combined effect with …
infants and whether indoors passive smoking exposure has a combined effect with …
[HTML][HTML] Combinations of genetic variants occurring exclusively in patients
E Mellerup, GL Møller - Computational and Structural Biotechnology …, 2017 - Elsevier
In studies of polygenic disorders, scanning the genetic variants can be used to identify
variant combinations. Combinations that are exclusively found in patients can be separated …
variant combinations. Combinations that are exclusively found in patients can be separated …
Combinations of genetic variants associated with bipolar disorder
E Mellerup, OA Andreassen, B Bennike, H Dam… - Plos one, 2017 - journals.plos.org
The main objective of the study was to find genetic variants that in combination are
significantly associated with bipolar disorder. In previous studies of bipolar disorder …
significantly associated with bipolar disorder. In previous studies of bipolar disorder …
Alcohol intake and Alcohol–SNP interactions Associated with prostate Cancer aggressiveness
Excessive alcohol intake is a well-known modifiable risk factor for many cancers. It is still
unclear whether genetic variants or single nucleotide polymorphisms (SNPs) can modify …
unclear whether genetic variants or single nucleotide polymorphisms (SNPs) can modify …
New glutamatergic target for alcohol and substance use disorder medications
C Vadasz, M Saito - Psychopharmacology, 2014 - Springer
Traditionally, theories of dopamine reward (Wise 1996; Wise and Bozarth 1987) dominated
the field of alcohol and substance use disorder. The brain's most abundant neurotransmitter …
the field of alcohol and substance use disorder. The brain's most abundant neurotransmitter …
Test for association of common variants in GRM7 with alcohol consumption
Recent work using a mouse model has identified the glutamate metabotropic receptor 7
(Grm7) gene as a strong candidate gene for alcohol consumption. Although there has been …
(Grm7) gene as a strong candidate gene for alcohol consumption. Although there has been …
[PDF][PDF] Allele-Specific Network Reveals Combinatorial Interaction That Transcends Small Effects in Psoriasis
Hundreds of genetic markers have shown associations with various complex diseases, yet
the ''missing heritability''remains alarmingly elusive. Combinatorial interactions may account …
the ''missing heritability''remains alarmingly elusive. Combinatorial interactions may account …