1, 3, 4-Thiadiazole: synthesis, reactions, and applications in medicinal, agricultural, and materials chemistry

Y Hu, CY Li, XM Wang, YH Yang, HL Zhu - Chemical reviews, 2014 - ACS Publications
Over the past decades, the bulk of chemists' interests have been on heterocyclic compounds
and their various derivatives as well as their applications in the pharmaceutical and …

An overview of quinazolines: Pharmacological significance and recent developments

V Alagarsamy, K Chitra, G Saravanan… - European journal of …, 2018 - Elsevier
Most of the drugs and pharmacologically relevant molecules possess heterocyclic ring
structures and presence of hetero atoms or groupings divulges privileged specificities in …

Chemical characteristics, synthetic methods, and biological potential of quinazoline and quinazolinone derivatives

M Asif - International journal of medicinal chemistry, 2014 - Wiley Online Library
The heterocyclic fused rings quinazoline and quinazolinone have drawn a huge
consideration owing to their expanded applications in the field of pharmaceutical chemistry …

Thiadiazole—A promising structure in medicinal chemistry

Y Li, J Geng, Y Liu, S Yu, G Zhao - ChemMedChem, 2013 - Wiley Online Library
Many compounds containing a five‐membered heterocyclic ring display exceptional
chemical properties and versatile biological activities. In this Minireview, thiadiazoles are …

Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4 (3) H-ones

KS Kumar, S Ganguly, R Veerasamy… - European journal of …, 2010 - Elsevier
A new series of 3-(benzylideneamino)-2-phenylquinazoline-4 (3H)-ones were prepared
through Schiff base formation of 3-amino-2-phenyl quinazoline-4 (3) H-one with various …

Visible light photocatalytic aerobic oxygenation of indoles and pH as a chemoselective switch

C Zhang, S Li, F Bureš, R Lee, X Ye, Z Jiang - ACS Catalysis, 2016 - ACS Publications
An efficient chemodivergent strategy for visible light photocatalysis is developed. In the
presence of a dicyanopyrazine-derived chromophore (DPZ) photocatalyst, aerobic …

Quinazolines: new horizons in anticonvulsant therapy

VG Ugale, SB Bari - European journal of medicinal chemistry, 2014 - Elsevier
The search for novel anticonvulsants with more selectivity and lower toxicity continues to be
an area of intensive investigation in medicinal chemistry. The potency and selectivity in the …

[HTML][HTML] Biological activities of imidazo [2, 1-b][1, 3, 4] thiadiazole derivatives: A review

BA Bhongade, S Talath, RA Gadad… - Journal of Saudi Chemical …, 2016 - Elsevier
Abstract Imidazo [2, 1-b][1, 3, 4] thiadiazole heterocycle was discovered during the 1950s.
Since then, many newer derivatives are being developed and evaluated for their biological …

Synthesis of 2-Amino-1,3,4-oxadiazoles and 2-Amino-1,3,4-thiadiazoles via Sequential Condensation and I2-Mediated Oxidative C–O/C–S Bond Formation

P Niu, J Kang, X Tian, L Song, H Liu, J Wu… - The Journal of …, 2015 - ACS Publications
2-Amino-substituted 1, 3, 4-oxadiazoles and 1, 3, 4-thiadiazoles were synthesized via
condensation of semicarbazide/thiosemicarbazide and the corresponding aldehydes …

2, 5-Disubstituted-1, 3, 4-oxadiazoles/thiadiazole as surface recognition moiety: Design and synthesis of novel hydroxamic acid based histone deacetylase inhibitors

H Rajak, A Agarawal, P Parmar, BS Thakur… - Bioorganic & medicinal …, 2011 - Elsevier
The enzymatic inhibition of histone deacetylase activity has come out as a novel and
effectual means for the treatment of cancer. Two novel series of 2-[5-(4-substitutedphenyl) …