Lipids are insoluble in water and therefore cholesterol and triglycerides need to be
transported in association with proteins (ie, lipoproteins) in the bloodstream. Lipoproteins …

β-Sitosterol (SIT), a white powdery organic substance with a molecular formula of C29H50O,
is one of the most abundant naturally occurring phytosterols in plants. With a chemical …

As atherosclerosis begins in childhood, early diagnosis and treatment of familial
hypercholesterolemia (FH) is considered necessary. The basic diagnosis of pediatric FH …

The ATP‐binding cassette (ABC) transporter superfamily is one of the largest membrane
protein families existing in wide spectrum of organisms from prokaryotes to human. ABC …

Familial hypercholesterolemia (FH) is an inherited disorder with retarded clearance of
plasma LDL caused by mutations of the genes involved in the LDL receptor-mediated …

In Japan, a super-aged society, deaths from atherosclerotic cardiovascular disease
(ASCVD), especially cardiac diseases including coronary artery disease (CAD) such as …

Sitosterolemia is an inherited metabolic disorder characterized by increased levels of plant
sterols, such as sitosterol. This disease is caused by loss-of-function genetic mutations in …

The heart is the most vital organ of the human body; thus, its improper functioning has a
significant impact on human life. Coronary artery disease (CAD) is a disease of the coronary …

Plants contain numerous glycoconjugates that are metabolized by specific
glucosyltransferases and hydrolyzed by specific glycosidases, some also catalyzing …

The liver is beyond any doubt the most important metabolic organ of the human body. This
function requires an intensive crosstalk within liver cellular structures, but also with other …