Insights into the structures and multimeric status of APOBEC proteins involved in viral restriction and other cellular functions
XS Chen - Viruses, 2021 - mdpi.com
Apo lipoprotein B mRNA e diting c atalytic polypeptide-like (APOBEC) proteins belong to a
family of deaminase proteins that can catalyze the deamination of cytosine to uracil on …
family of deaminase proteins that can catalyze the deamination of cytosine to uracil on …
Deamination hotspots among APOBEC3 family members are defined by both target site sequence context and ssDNA secondary structure
YZ McDaniel, D Wang, RP Love… - Nucleic acids …, 2020 - academic.oup.com
The human apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3 (APOBEC3,
A3) family member proteins can deaminate cytosines in single-strand (ss) DNA, which …
A3) family member proteins can deaminate cytosines in single-strand (ss) DNA, which …
[PDF][PDF] Adipocyte death preferentially induces liver injury and inflammation through the activation of chemokine (C‐C motif) receptor 2‐positive macrophages and …
Adipocyte death occurs under various physiopathological conditions, including obesity and
alcohol drinking, and can trigger organ damage particularly in the liver, but the underlying …
alcohol drinking, and can trigger organ damage particularly in the liver, but the underlying …
[HTML][HTML] Molecular basis of genetic variation of viruses: Error-prone replication
E Domingo - Virus as Populations, 2020 - ncbi.nlm.nih.gov
Genetic variation is a necessity of all biological systems. Viruses use all known mechanisms
of variation; mutation, several forms of recombination, and segment reassortment in the case …
of variation; mutation, several forms of recombination, and segment reassortment in the case …
Human papillomavirus 16 E7 stabilizes APOBEC3A protein by inhibiting cullin 2-dependent protein degradation
ABSTRACT APOBEC3 (A3) mutation signatures have been observed in a variety of human
cancer genomes, including those of cervical and head and neck cancers caused by human …
cancer genomes, including those of cervical and head and neck cancers caused by human …
Unraveling the enzyme-substrate properties for APOBEC3A-Mediated RNA editing
K Kim, AB Shi, K Kelley, XS Chen - Journal of Molecular Biology, 2023 - Elsevier
The APOBEC3 family of human cytidine deaminases is involved in various cellular
processes, including the innate and acquired immune system, mostly through inducing C-to …
processes, including the innate and acquired immune system, mostly through inducing C-to …
A unique subset of low-risk Wilms tumors is characterized by loss of function of TRIM28 (KAP1), a gene critical in early renal development: A Children's Oncology …
AE Armstrong, S Gadd, V Huff, DS Gerhard, JS Dome… - PLoS …, 2018 - journals.plos.org
This study explores the genomic alterations that contribute to the formation of a unique
subset of low-risk, epithelial differentiated, favorable histology Wilms tumors (WT), tumors …
subset of low-risk, epithelial differentiated, favorable histology Wilms tumors (WT), tumors …
[PDF][PDF] A functional variant in ubiquitin conjugating enzyme E2 L3 contributes to hepatitis B virus infection and maintains covalently closed circular DNA stability by …
L Zhou, JH Ren, ST Cheng, HM Xu, WX Chen… - …, 2019 - Wiley Online Library
Hepatitis B virus (HBV) infection is a common infectious disease, in which nuclear covalently
closed circular DNA (cccDNA) plays a key role in viral persistence, viral reactivation after …
closed circular DNA (cccDNA) plays a key role in viral persistence, viral reactivation after …
The cytidine deaminase APOBEC3 family is subject to transcriptional regulation by p53
D Menendez, TA Nguyen, J Snipe, MA Resnick - Molecular Cancer Research, 2017 - AACR
Abstract The APOBEC3 (A3) family of proteins are DNA cytidine deaminases that act as
sentinels in the innate immune response against retroviral infections and are responsive to …
sentinels in the innate immune response against retroviral infections and are responsive to …
[HTML][HTML] Engineered CBEs based on Macaca fascicularis A3A with improved properties for precise genome editing
CY Ren, YS Liu, YS He, LP Zhang, JH Rao, Y Rao… - Cell Reports, 2024 - cell.com
Cytidine deaminase defines the properties of cytosine base editors (CBEs) for C-to-T
conversion. Replacing the cytidine deaminase rat APOBEC1 (rA1) in CBEs with a human …
conversion. Replacing the cytidine deaminase rat APOBEC1 (rA1) in CBEs with a human …