[HTML][HTML] Translational strategies and systems biology insights for blood-brain barrier opening and delivery in brain tumors and Alzheimer's disease

G Song, P Plumlee, JY Ahn, STC Wong… - Biomedicine & …, 2023 - Elsevier
The blood-brain barrier (BBB) plays a critical role in determining the effectiveness of
systemic treatments for brain diseases. Over the years, several innovative approaches in …

FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer's disease

AJ Lee, NS Raghavan, P Bhattarai, T Siddiqui… - Acta …, 2022 - Springer
Alzheimer's disease (AD) has been associated with cardiovascular and cerebrovascular risk
factors (CVRFs) during middle age and later and is frequently accompanied by …

Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease

P Bhattarai, TI Gunasekaran, ME Belloy… - Acta …, 2024 - Springer
The risk of developing Alzheimer's disease (AD) significantly increases in individuals
carrying the APOEε4 allele. Elderly cognitively healthy individuals with APOEε4 also exist …

ABCA7‐dependent Neuropeptide‐Y signalling is a resilience mechanism required for synaptic integrity in Alzheimer's disease

H Tayran, E Yilmaz, P Bhattarai, Y Min… - Alzheimer's & …, 2024 - Wiley Online Library
Background Genetic variations have emerged as crucial players in the etiology of
Alzheimer's disease (AD), and they serve for a better understanding of the disease …

Rare genetic variation in fibronectin 1 (FN1) protects against APOE ɛ4 in Alzheimer's Disease

P Bhattarai, TI Gunasekaran, BT Uzrek… - Alzheimer's & …, 2024 - Wiley Online Library
Background APOEε4 significantly increases the risk of developing Alzheimer's disease (AD).
Cognitively healthy APOEε4‐carriers exist, suggesting potential protective mechanisms …