Bilirubin acts as a multipotent guardian of cardiovascular integrity: more than just a radical idea

AC Bulmer, B Bakrania, EF Du Toit… - American Journal …, 2018 - journals.physiology.org
Bilirubin, a potentially toxic catabolite of heme and indicator of hepatobiliary insufficiency,
exhibits potent cardiac and vascular protective properties. Individuals with Gilbert's …

[HTML][HTML] An integrated approach to coronary heart disease diagnosis and clinical management

T Infante, E Forte, C Schiano, C Cavaliere… - American journal of …, 2017 - ncbi.nlm.nih.gov
The major issue in coronary heart disease (CHD) diagnosis and management is that
symptoms onset in an advanced state of disease. Despite the availability of several clinical …

Bilirubin nanoparticles protect against cardiac ischemia/reperfusion injury in mice

W Ai, S Bae, Q Ke, S Su, R Li, Y Chen… - Journal of the …, 2021 - Am Heart Assoc
Background Ischemia/reperfusion (I/R) injury causes overproduction of reactive oxygen
species, which are the major culprits of oxidative stress that leads to inflammation …

Evidence of association of circulating epigenetic-sensitive biomarkers with suspected coronary heart disease evaluated by Cardiac Computed Tomography

T Infante, E Forte, C Schiano, B Punzo, F Cademartiri… - PLoS …, 2019 - journals.plos.org
Circulating biomarkers available in clinical practice do not allow to stratify patients with
coronary heart disease (CHD) prior the onset of a clinically relevant event. We evaluated the …

[PDF][PDF] Arterial stiffness and central arterial wave reflection are associated with serum uric acid, total bilirubin, and neutrophil-to-lymphocyte ratio in patients with …

A Tanindi, AF Erkan, A Alhan… - The Anatolian Journal of …, 2015 - jag.journalagent.com
Objective: Total bilirubin (TB) was recently recognized as an endogenous anti-inflammatory
and anti-oxidant molecule. Uric acid (UA) takes part in cardiovascular diseases by inducing …

Serum Bilirubin in the Czech Population―Relationship to the Risk of Myocardial Infarction in Males―

L Eremiasova, JA Hubacek, V Danzig… - Circulation …, 2020 - jstage.jst.go.jp
Background: The potential antiatherogenic role of bilirubin is generally acknowledged, so
the aim of this study was to determine serum bilirubin concentrations and the prevalence of …

Role of bilirubin in the prognosis of coronary artery disease and its relationship with cardiovascular risk factors: a meta-analysis

X Li, C Zhao, C Pan, G Jiang, B Zhang - BMC Cardiovascular Disorders, 2022 - Springer
Background Bilirubin is a heme catabolism product with antioxidant, anti-inflammatory, and
anti-apoptotic properties and is implicated in the prognosis of several diseases. This study …

[HTML][HTML] Bilirubin in coronary artery disease: Cytotoxic or protective?

N Gupta, T Singh, R Chaudhary, SK Garg… - World journal of …, 2016 - ncbi.nlm.nih.gov
Bilirubin has traditionally been considered a cytotoxic waste product. However, recent
studies have shown bilirubin to have anti-oxidant, anti-inflammatory, vasodilatory, anti …

The relationship between serum levels of total bilirubin and coronary plaque vulnerability

KF Zhu, YM Wang, YQ Wang, NF Wang - Coronary Artery Disease, 2016 - journals.lww.com
Objectives Previous studies have reported that serum total bilirubin provides some
protection against coronary artery disease (CAD); however, the relationship between serum …

[PDF][PDF] Serum total bilirubin levels and disease severity in patients with stable coronary artery disease

J Yu, JL Han, GS Wang, LJ Guo, W Gao - Herz, 2017 - researchgate.net
Serum total bilirubin (STB) is a final product of heme metabolism. Many studies have shown
that bilirubin may protect against atherosclerosis due to its antioxidant properties [1–3] …